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of each paper to access MedLine abstract at NLM site Role of age, bowel function and parity on anorectocele pathogenesis according to cinedefecography and anal manometry evaluation. Soares FA, Regadas FS, Murad-Regadas SM, Rodrigues LV, Silva FR, Escalante RD, Bezerra RF. Colorectal Dis. 2008 Dec 22 Practical performance of defecography for the evaluation of constipation and incontinence. Brennan D, Williams G, Kruskal J. Semin Ultrasound CT MR. 2008 Dec;29(6):420-6. Discriminative Value of Anorectal Manometry in Clinical Practice. Raza N, Bielefeldt K. Dig Dis Sci. 2008 Dec 18. Lubiprostone for constipation and irritable bowel syndrome with constipation. Tuteja AK, Rao SS. Expert Rev Gastroenterol Hepatol. 2008 Dec;2(6):727-33. Optimal treatment of chronic constipation in managed care: review and roundtable discussion. Eoff JC. J Manag Care Pharm. 2008 Nov;14(9 Suppl A):1-15. Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation--a 12-week, randomized, double-blind, placebo-controlled study. Quigley EM, Vandeplassche L, Kerstens R, Ausma J. Aliment Pharmacol Ther. 2009 Feb 1;29(3):315-28. Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects. Sweetser S, Busciglio IA, Camilleri M, Bharucha AE, Szarka LA, Papathanasopoulos A, Burton DD, Eckert DJ, Zinsmeister AR. Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G295-301. Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain. Simpson K, Leyendecker P, Hopp M, Müller-Lissner S, Löwenstein O, De Andrés J, Troy Ferrarons J, Bosse B, Krain B, Nichols T, Kremers W, Reimer K. Curr Med Res Opin. 2008 Dec;24(12):3503-12 Macrogol (polyethylene glycol) laxatives in children with functional constipation and faecal impaction: a systematic review. Candy D, Belsey J. Arch Dis Child. 2009 Feb;94(2):156-60. Epub 2008 Nov 19. Review. Management of neurogenic bowel dysfunction in the community after spinal cord injury: a postal survey in the United Kingdom. Coggrave M, Norton C, Wilson-Barnett J. Spinal Cord. 2008 Nov 18. Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome--results of two randomized, placebo-controlled studies. Drossman DA, Chey WD, Johanson JF, Fass R, Scott C, Panas R, Ueno R. Aliment Pharmacol Ther. 2009 Feb 1;29(3):329-41. Blinded comparison of faecal loading on plain radiography versus radio-opaque marker transit studies in the assessment of constipation. Cowlam S, Vinayagam R, Khan U, Marsden S, Minty I, Moncur P, Bain I, Yiannakou YJ. Clin Radiol. 2008 Dec;63(12):1326-31. Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives. Tack J, van Outryve M, Beyens G, Kerstens R, Vandeplassche L. Gut. 2009 Mar;58(3):357-65. The constipated child: is there a correlation between symptoms and manometric findings? Feinberg L, Mahajan L, Steffen R. J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):607-11. A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial. Kokke FT, Scholtens PA, Alles MS, Decates TS, Fiselier TJ, Tolboom JJ, Kimpen JL, Benninga MA. J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):592-7. Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach. Reimer K, Hopp M, Zenz M, Maier C, Holzer P, Mikus G, Bosse B, Smith K, Buschmann-Kramm C, Leyendecker P. Pharmacology. 2009;83(1):10-7. Epub 2008 Oct 28. Review. Correlation of gut hormones with irritable bowel syndrome. Zhang H, Yan Y, Shi R, Lin Z, Wang M, Lin L. Digestion. 2008;78(2-3):72-6. Surgical management of colonic volvulus during same hospital admission. Alam MK, Fahim F, Al-Akeely MH, Qazi SA, Al-Dossary NF. Saudi Med J. 2008 Oct;29(10):1438-42. Prospective multicentre clinical trial of stapled transanal rectal resection for obstructive defaecation syndrome. Arroyo A, González-Argenté FX, García-Domingo M, Espin-Basany E, De-la-Portilla F, Pérez-Vicente F, Calpena R. Br J Surg. 2008 Dec;95(12):1521-7. Renzapride: a new drug for the treatment of constipation in the irritable bowel syndrome. Scarpellini E, Tack J. Expert Opin Investig Drugs. 2008 Nov;17(11):1663-70. Review. PMID: 18922103 [PubMed - indexed for MEDLINE]The effect of naloxone-3-glucuronide on colonic transit time in healthy men after acute morphine administration: a placebo-controlled double-blinded crossover preclinical volunteer study. Netzer P, Sendensky A, Wissmeyer MP, Baumeler S, Batista C, Scheurer U, Krause T, Reber P, Brenneisen R. Aliment Pharmacol Ther. 2008 Dec 1;28(11-12):1334-41. Clinical, physiological and radiological assessment of rectovaginal septum reinforcement with mesh for complex rectocele. D'Hoore A, Vanbeckevoort D, Penninckx F. Br J Surg. 2008 Oct;95(10):1264-72. Prospective study of colonic irrigation for the treatment of defaecation disorders. Koch SM, Melenhorst J, van Gemert WG, Baeten CG. Br J Surg. 2008 Oct;95(10):1273-9. Subtotal colectomy with antiperistaltic cecoproctostomy for selected patients with slow transit constipation-from Chinese report. Jiang CQ, Qian Q, Liu ZS, Bangoura G, Zheng KY, Wu YH. Int J Colorectal Dis. 2008 Dec;23(12):1251-6 Stapled trans-anal rectal resection (STARR) by a new dedicated device for the surgical treatment of obstructed defaecation syndrome caused by rectal intussusception and rectocele: early results of a multicenter prospective study. Renzi A, Talento P, Giardiello C, Angelone G, Izzo D, Di Sarno G. Int J Colorectal Dis. 2008 Oct;23(10):999-1005. A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Wald A, Scarpignato C, Mueller-Lissner S, Kamm MA, Hinkel U, Helfrich I, Schuijt C, Mandel KG. Aliment Pharmacol Ther. 2008 Oct 1;28(7):917-30. Long-term results of antegrade colonic enema in adult patients: assessment of functional results. Worsøe J, Christensen P, Krogh K, Buntzen S, Laurberg S. Dis Colon Rectum. 2008 Oct;51(10):1523-8 Successful physical therapy for constipation related to puborectalis dyssynergia improves symptom severity and quality of life. Lewicky-Gaupp C, Morgan DM, Chey WD, Muellerleile P, Fenner DE. Dis Colon Rectum. 2008 Nov;51(11):1686-91. Clinical and morphologic correlation after stapled transanal rectal resection for obstructed defecation syndrome. Dindo D, Weishaupt D, Lehmann K, Hetzer FH, Clavien PA, Hahnloser D. Dis Colon Rectum. 2008 Dec;51(12):1768-74. Validity of segmental transit studies used in routine clinical practice, to characterize defaecatory disorder in patients with functional constipation. Cowlam S, Khan U, Mackie A, Varma JS, Yiannankou Y. Colorectal Dis. 2008 Oct;10(8):818-22. Obstructive defecation in middle-aged women. Varma MG, Hart SL, Brown JS, Creasman JM, Van Den Eeden SK, Thom DH. Dig Dis Sci. 2008 Oct;53(10):2702-9. Intramuscular neostigmine and glycopyrrolate safely accelerated bowel evacuation in patients with spinal cord injury and defecatory disorders. Rosman AS, Chaparala G, Monga A, Spungen AM, Bauman WA, Korsten MA. Dig Dis Sci. 2008 Oct;53(10):2710-3. Laparoscopic ventral rectopexy for obstructed defecation syndrome. van den Esschert JW, van Geloven AA, Vermulst N, Groenedijk A, de Wit LT, Gerhards MF. Surg Endosc. 2008 Dec;22(12):2728-32. Cowlam S, Vinayagam R, Khan U, Marsden S, Minty I, Moncur P, Bain I, Yiannakou YJ. Clin Radiol. 2008 Dec;63(12):1326-31.New approaches to the treatment of opioid-induced constipation. Holzer P. Eur Rev Med Pharmacol Sci. 2008 Aug;12 Suppl 1:119-27. Review. Perona M, Mearin F, Guilera M, Mínguez M, Ortiz V, Montoro M, Serra J, Casanova C, Rey E, Alarcón O, Bujanda L, Lima A, Andreu M, Castro M, López A, Carrillo R, Sempere L, Badia X; Study group on functional gastrointestinal disorders from the Spanish Association of Gastroenteroloy (AEG). Med Clin (Barc). 2008 Sep 27;131(10):371-7. Spanish.A Gap in Our Understanding: Chronic Constipation and Its Comorbid Conditions. Talley NJ, Lasch KL, Baum CL. Clin Gastroenterol Hepatol. 2008 Sep 30.Constipation does not develop following elective hysterectomy: a prospective, controlled study. Sperber AD, Morris CB, Greemberg L, Bangdiwala SI, Goldstein D, Sheiner E, Rusabrov Y, Hu Y, Katz M, Freud T, Neville A, Drossman DA. Neurogastroenterol Motil. 2008 Sep 16. [ Hagiwara N, Tomita R. Hepatogastroenterology. 2008 Jul-Aug;55(85):1298-303. Mazumdar A, Mishra S, Bhatnagar S, Gupta D. Am J Hosp Palliat Care. 2008 Aug-Sep;25(4):282-4. Bell TJ, Panchal SJ, Miaskowski C, Bolge SC, Milanova T, Williamson R.Comparative study between biofeedback retraining and botulinum neurotoxin in the treatment of anismus patients. Farid M, El Monem HA, Omar W, El Nakeeb A, Fikry A, Youssef T, Yousef M, Ghazy H, Fouda E, El Metwally T, Khafagy W, Ahmed S, El Awady S, Morshed M, El Lithy R. Int J Colorectal Dis. 2009 Jan;24(1):115-20. Jiang CQ, Qian Q, Liu ZS, Bangoura G, Zheng KY, Wu YH. Int J Colorectal Dis. 2008 Dec;23(12):1251-6.Clinical pharmacology of lubiprostone, a chloride channel activator in defecation disorders. Ginzburg R, Ambizas EM. Expert Opin Drug Metab Toxicol. 2008 Aug;4(8):1091-7. Wattchow D, Brookes S, Murphy E, Carbone S, de Fontgalland D, Costa M. Neurogastroenterol Motil. 2008 Dec;20(12):1298-305. Koh CE, Young CJ, Young JM, Solomon MJ. 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Roovers JP, van der Bom JG, van der Vaart CH; HysVA Study Group. Dis Colon Rectum. 2008 Jul;51(7):1068-72;Novel concepts in the diagnosis, pathophysiology and management of idiopathic megabowel. Gladman MA, Knowles CH. Colorectal Dis. 2008 Jul;10(6):531-8; discussion 538-40.Treatment of neurogenic bowel dysfunction using transanal irrigation: a multicenter Italian study. Del Popolo G, Mosiello G, Pilati C, Lamartina M, Battaglino F, Buffa P, Redaelli T, Lamberti G, Menarini M, Di Benedetto P, De Gennaro M. Spinal Cord. 2008 Jul;46(7):517-22.Fayyaz M, Lackner JM. Serotonin receptor modulators in the treatment of irritable bowel syndrome. Ther Clin Risk Manag. 2008 Feb;4(1):41-8. Foroutan HR, Hosseini SM, Banani SA, Bahador A, Sabet B, Zeraatian S, Banani SJ.Comparison of botulinium toxin injection and posterior anorectal myectomy in treatment of internal anal sphincter achalasia. Indian J Gastroenterol. 2008 Mar-Apr;27(2):62-5. Guarnieri A, Cesaretti M, Tirone A, Vuolo G, Verre L, Savelli V, Piccolomini A, Di Cosmo L, Carli AF, Burroni M, Pitzalis M.[Stapled transanal rectal resection (STARR) in the treatment of rectocele: personal experience] Chir Ital. 2008 Mar-Apr;60(2):243-8. Italian. Lacy BE, Levy LC.Lubiprostone: a novel treatment for chronic constipation. Clin Interv Aging. 2008;3(2):357-64. Liu TT, Chen CL, Yi CH.Anorectal manometry in patients with chronic constipation: a single-center experience. Hepatogastroenterology. 2008 Mar-Apr;55(82-83):426-9. Lewicky-Gaupp C, Morgan DM, Chey WD, Muellerleile P, Fenner DE.Successful Physical Therapy for Constipation Related to Puborectalis Dyssynergia Improves Symptom Severity and Quality of Life. Dis Colon Rectum. 2008 Jun 27. Dindo D, Weishaupt D, Lehmann K, Hetzer FH, Clavien PA, Hahnloser D.Clinical and Morphologic Correlation after Stapled Transanal Rectal Resection for Obstructed Defecation Syndrome. Dis Colon Rectum. 2008 Jun 25. Rege S, Lafferty T.Life-threatening constipation associated with clozapine. Australas Psychiatry. 2008 Jun;16(3):216-9. Kress HG.Clinical update on the pharmacology, efficacy and safety of transdermal buprenorphine. Eur J Pain. 2008 Jun 20 Guest JF, Clegg JP, Helter MT.Cost-effectiveness of macrogol 4000 compared to lactulose in the treatment of chronic functional constipation in the UK. Curr Med Res Opin. 2008 Jul;24(7):1841-52. Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ.Ambulatory care for constipation in the United States, 1993-2004. Am J Gastroenterol. 2008 Jul;103(7):1746-53. Rahimi R, Nikfar S, Abdollahi M.Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin Ther. 2008 May;30(5):884-901. Ono S, Komada Y, Kamiya T, Shirakawa S.A pilot study of the relationship between bowel habits and sleep health by actigraphy measurement and fecal flora analysis. J Physiol Anthropol. 2008 May;27(3):145-51. De Paula JA, Carmuega E, Weill R.Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation. Acta Gastroenterol Latinoam. 2008 Mar;38(1):16-25. Dinning PG, Szczesniak MM, Cook IJ.Twenty-four hour spatiotemporal mapping of colonic propagating sequences provides pathophysiological insight into constipation. Neurogastroenterol Motil. 2008 Sep;20(9):1017-21. Stefan R, Tudor B, Friedrich H, Anton S.Postoperative Course and Long Term Follow Up after Colectomy for Slow Transit Constipation - Is Surgery an Appropriate Approach? Colorectal Dis. 2008 May 29. Sciaudone G, Di Stazio C, Guadagni I, Selvaggi F.Rectal diverticulum: a new complication of STARR procedure for obstructed defecation. Tech Coloproctol. 2008 Mar;12(1):61-3. Camilleri M, Kerstens R, Rykx A, Vandeplassche L.A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med. 2008 May 29;358(22):2344-54. Thomas J, Karver S, Cooney GA, Chamberlain BH, Watt CK, Slatkin NE, Stambler N, Kremer AB, Israel RJ.Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med. 2008 May 29;358(22):2332-43. Grover M, Kanazawa M, Palsson OS, Chitkara DK, Gangarosa LM, Drossman DA, Whitehead WE.Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress. Neurogastroenterol Motil. 2008 Sep;20(9):998-1008. Jiang X, Locke GR 3rd, Choung RS, Zinsmeister AR, Schleck CD, Talley NJ.Prevalence and risk factors for abdominal bloating and visible distention: a population-based study. Gut. 2008 Jun;57(6):756-63. Chey WD, Paré P, Viegas A, Ligozio G, Shetzline MA.Tegaserod for female patients suffering from IBS with mixed bowel habits or constipation: a randomized controlled trial. Am J Gastroenterol. 2008 May;103(5):1217-25. Mihaylov S, Stark C, McColl E, Steen N, Vanoli A, Rubin G, Curless R, Barton R, Bond J.Stepped treatment of older adults on laxatives. The STOOL trial. Health Technol Assess. 2008 May;12(13):iii-iv, ix-139. Cowlam S, Khan U, Mackie A, Varma JS, Yiannankou Y.Validity of segmental transit studies used in routine clinical practice, to characterise defaecatory disorder in patients with functional constipation. Colorectal Dis. 2008 May 3. McCrea GL, Miaskowski C, Stotts NA, Macera L, Varma MG.Pathophysiology of constipation in the older adult. World J Gastroenterol. 2008 May 7;14(17):2631-8. Review. Daley AJ, Grimmett C, Roberts L, Wilson S, Fatek M, Roalfe A, Singh S.The effects of exercise upon symptoms and quality of life in patients diagnosed with irritable bowel syndrome: a randomised controlled trial. Int J Sports Med. 2008 Sep;29(9):778-82. Camilleri M, McKinzie S, Busciglio I, Low PA, Sweetser S, Burton D, Baxter K, Ryks M, Zinsmeister AR.Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol. 2008 Jul;6(7):772-81. Agrawal A, Houghton LA, Lea R, Morris J, Reilly B, Whorwell PJ.Bloating and distention in irritable bowel syndrome: the role of visceral sensation. Gastroenterology. 2008 Jun;134(7):1882-9. Palmer SE, McLean RM, Ellis PM, Harrison-Woolrych M.Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 cases. J Clin Psychiatry. 2008 May;69(5):759-68. Review. O'Boyle AL, O'Boyle JD, Magann EF, Rieg TS, Morrison JC, Davis GD.Anorectal symptoms in pregnancy and the postpartum period. J Reprod Med. 2008 Mar;53(3):151-4. Belo GM, Diniz Ada S, Pereira AP.[Effect of partially hidrolized guar-gum in the treatment of functional constipation among hospitalized patients] Arq Gastroenterol. 2008 Jan-Mar;45(1):93-5. Portuguese. Lacerda-Filho A, Lima MJ, Magalhães MF, Paiva Rde A, Cunha-Melo JR.Chronic constipation - the role of clinical assessment and colorectal physiologic tests to obtain an etiologic diagnosis. Arq Gastroenterol. 2008 Jan-Mar;45(1):50-7. Tuteja AK, Talley NJ, Joos SK, Tolman KG, Hickam DH.Abdominal bloating in employed adults: prevalence, risk factors, and association with other bowel disorders. Am J Gastroenterol. 2008 May;103(5):1241-8. Schwandner O, Stuto A, Jayne D, Lenisa L, Pigot F, Tuech JJ, Scherer R, Nugent K, Corbisier F, Basany EE, Hetzer FH.Decision-making algorithm for the STARR procedure in obstructed defecation syndrome: position statement of the group of STARR Pioneers. Surg Innov. 2008 Jun;15(2):105-9. Pinedo G, Zarate AJ, Garcia E, Molina ME, Lopez F, Zúñiga A.Laparoscopic total colectomy for colonic inertia: surgical and functional results. Surg Endosc. 2008 Apr 10. Drouault-Holowacz S, Bieuvelet S, Burckel A, Cazaubiel M, Dray X, Marteau P.A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol. 2008 Feb;32(2):147-52. Shariati A, Maceda JS, Hale DS.High-fiber diet for treatment of constipation in women with pelvic floor disorders. Obstet Gynecol. 2008 Apr;111(4):908-13. Bratten JR, Spanier J, Jones MP.Lactulose breath testing does not discriminate patients with irritable bowel syndrome from healthy controls. Am J Gastroenterol. 2008 Apr;103(4):958-63. Park JH, Baek YH, Park DI, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Rhee PL.Analysis of rectal dynamic and static compliances in patients with irritable bowel syndrome. Int J Colorectal Dis. 2008 Jul;23(7):659-64. Frascio M, Stabilini C, Ricci B, Marino P, Fornaro R, De Salvo L, Mandolfino F, Lazzara F, Gianetta E.Stapled transanal rectal resection for outlet obstruction syndrome: results and follow-up. World J Surg. 2008 Jun;32(6):1110-5. Varma MG, Hart SL, Brown JS, Creasman JM, Van Den Eeden SK, Thom DH.Obstructive Defecation in Middle-aged Women. Dig Dis Sci. 2008 Oct;53(10):2702-9. Holzer B, Rosen HR, Novi G, Ausch C, Hölbling N, Hofmann M, Schiessel R.Sacral nerve stimulation in patients with severe constipation. Dis Colon Rectum. 2008 May;51(5):524-29; discussion 529-30. van den Esschert JW, van Geloven AA, Vermulst N, Groenedijk A, de Wit LT, Gerhards MF.Laparoscopic ventral rectopexy for obstructed defecation syndrome. Surg Endosc. 2008 Mar 5. Schmulson Wasserman M, Francisconi C, Olden K, Aguilar Paíz L, Bustos-Fernández L, Cohen H, Passos MC, González-Martínez MA, Iade B, Iantorno G, Ledesma Ginatta C, López-Colombo A, Pérez CL, Madrid-Silva AM, Quilici F, Quintero Samudio I, Rodríguez Varón A, Suazo J, Valenzuela J, Zolezzi A.[The Latin-American Consensus on Chronic Constipation] Gastroenterol Hepatol. 2008 Feb;31(2):59-74. Spanish. Meurette G, Siproudhis L, Regenet N, Frampas E, Proux M, Lehur PA.Poor symptomatic relief and quality of life in patients treated for "solitary rectal ulcer syndrome without external rectal prolapse". Int J Colorectal Dis. 2008 May;23(5):521-6. Peppas G, Alexiou VG, Mourtzoukou E, Falagas ME.Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008 Feb 12;8:5. Review. 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Correlating clinical and radiological findings in surgery for obstructed defecation. Colorectal Dis. 2008 Jun;10(5):446-52. Danjo K, Sakamoto J, Iwane S, Tamura K, Nakaji S, Fukuda S, Murakami H, Shimoyama T, Takahashi I, Umeda T.Effects of cellulose supplementation on fecal consistency and fecal weight. Dig Dis Sci. 2008 Mar;53(3):712-8. Murad-Regadas SM, Regadas FS, Rodrigues LV, Silva FR, Soares FA, Escalante RD.A novel three-dimensional dynamic anorectal ultrasonography technique (echodefecography) to assess obstructed defecation, a comparison with defecography. Surg Endosc. 2008 Apr;22(4):974-9. Slawik S, Soulsby R, Carter H, Payne H, Dixon AR.Laparoscopic ventral rectopexy, posterior colporrhaphy and vaginal sacrocolpopexy for the treatment of recto-genital prolapse and mechanical outlet obstruction. Colorectal Dis. 2008 Feb;10(2):138-43. 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