- Click on the title of each paper to access MedLine abstract at NLM site
Molecular biology and colorectal cancer markers

                                                          <return>

Onouchi S, Matsushita H, Moriya Y, Akasu T, Fujita S, Yamamoto S, Hasegawa H, Kitagawa Y, Matsumura Y. New method for colorectal cancer diagnosis based on SSCP analysis of DNA from exfoliated colonocytes in naturally evacuated feces. Anticancer Res. 2008 Jan-Feb;28(1A):145-50.

Chan SK, Griffith OL, Tai IT, Jones SJ. Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):543-52.

Ferreira S, Claro I, Lage P, Filipe B, Fonseca R, Sousa R, Francisco I, Chaves P, Albuquerque C, Leitão CN. Colorectal Adenomas in Young Patients: Microsatellite Instability is not a Useful Marker to Detect New Cases of Lynch Syndrome. Dis Colon Rectum. 2008 Feb 29;

Yoshiya G, Takahata T, Hanada N, Suzuki K, Ishiguro A, Saito M, Sasaki M, Fukuda S. Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer. J Gastroenterol Hepatol. 2008 Jan 17;

Han M, Liew CT, Zhang HW, Chao S, Zheng R, Yip KT, Song ZY, Li HM, Geng XP, Zhu LX, Lin JJ, Marshall KW, Liew CC. Novel blood-based, five-gene biomarker set for the detection of colorectal cancer. Clin Cancer Res. 2008 Jan 15;14(2):455-60.

Rimkus C, Friederichs J, Boulesteix AL, Theisen J, Mages J, Becker K, Nekarda H, Rosenberg R, Janssen KP, Siewert JR. Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer. Clin Gastroenterol Hepatol. 2008 Jan;6(1):53-61.

Rimkus C, Friederichs J, Boulesteix AL, Theisen J, Mages J, Becker K, Nekarda H, Rosenberg R, Janssen KP, Siewert JR. Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer. Clin Gastroenterol Hepatol. 2008 Jan;6(1):53-61.

Zlobec I, Minoo P, Baumhoer D, Baker K, Terracciano L, Jass JR, Lugli A. Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. Cancer. 2008 Feb 1;112(3):495-502.

Abd El All HS, Mishriky AM, Mohamed FA. Epidermal growth factor receptor in colorectal carcinoma: correlation with clinico-pathological prognostic factors. Colorectal Dis. 2008 Feb;10(2):170-8

Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA. VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol. 2008 Mar;15(3):738-44. Epub 2007 Nov 28.

Meng WJ, Sun XF, Tian C, Wang L, Yu YY, Zhou B, Gu J, Xia QJ, Li Y, Wang R, Zheng XL, Zhou ZG. Microsatellite instability did not predict individual survival in sporadic stage II and III rectal cancer patients. Oncology. 2007;72(1-2):82-8. Epub 2007 Nov 14.

Ponz-Sarvisé M, Rodríguez J, Viudez A, Chopitea A, Calvo A, García-Foncillas J, Gil-Bazo I.  Epidermal growth factor receptor inhibitors in colorectal cancer treatment: what's new? World J Gastroenterol. 2007 Nov 28;13(44):5877-87. Review.

Simiantonaki N, Taxeidis M, Jayasinghe C, Kirkpatrick CJ. Epithelial expression of VEGF receptors in colorectal carcinomas and their relationship to metastatic status. Anticancer Res. 2007 Sep-Oct;27(5A):3245-50.

de Heer P, de Bruin EC, Klein-Kranenbarg E, Aalbers RI, Marijnen CA, Putter H, de Bont HJ, Nagelkerke JF, van Krieken JH, Verspaget HW, van de Velde CJ, Kuppen PJ; Dutch Colorectal Cancer Group. Caspase-3 activity predicts local recurrence in rectal cancer. Clin Cancer Res. 2007 Oct 1;13(19):5810-5.

Li M, Li JY, Zhao AL, He JS, Zhou LX, Li YA, Gu J.  Survival stratification panel of colorectal carcinoma with combined expression of carcinoembryonic antigen, matrix metalloproteinases-2, and p27 kip1. Dis Colon Rectum. 2007 Nov;50(11):1887-98.

Araujo SE, Bernardo WM, Habr-Gama A, Kiss DR, Cecconello I.  DNA ploidy status and prognosis in colorectal cancer: a meta-analysis of published data. Dis Colon Rectum. 2007 Nov;50(11):1800-10. Review.

Xu F, Wang F, Di M, Huang Q, Wang M, Hu H, Jin Y, Dong J, Lai M. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res. 2007 Sep 1;13(17):5082-8.  

Bendardaf R, Lamlum H, Ristamaki R, Korkeila E, Syrjanen K, Pyrhonen S. Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. Tumour Biol. 2007;28(4):212-20. Epub 2007 Aug 24.  

Iddings DM, Koda EA, Grewal SS, Parker R, Saha S, Bilchik A. Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Arch Surg. 2007 Aug;142(8):738-44; discussion 744-5.  

Xi Y, Nakajima G, Gavin E, Morris CG, Kudo K, Hayashi K, Ju J. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA. 2007 Oct;13(10):1668-74.  

Kelder W, Braat A, van den Berg A, Platteel I, Hollema H, Groen H, Plukker J. Value of RT-PCR analysis of sentinel nodes in determining the pathological nodal status in colon cancer. Anticancer Res. 2007 Jul-Aug;27(4C):2855-9.

Zafirellis K, Agrogiannis G, Zachaki A, Gravani K, Karameris A, Kombouras C. Prognostic Significance of VEGF Expression Evaluated by Quantitative Immunohistochemical Analysis in Colorectal Cancer.
J Surg Res. 2007 Jul 25;

Ferroni P, Palmirotta R, Spila A, Martini F, Formica V, Portarena I, Del Monte G, Buonomo O, Roselli M, Guadagni F. Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer.
Oncology. 2006;71(3-4):176-84.

Collins VR, Meiser B, Ukoumunne OC, Gaff C, St John DJ, Halliday JL. The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing. Genet Med. 2007 May;9(5):290-297.

Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T. Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.
Clin Exp Metastasis. 2007;24(3):179-89.

Zumkeller N, Brenner H, Chang-Claude J, Hoffmeister M, Nieters A, Rothenbacher D. Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: Evidence from a case-control study in Germany. Eur J Cancer. 2007 May;43(8):1283-9.

Ewald J, Rodrigue CM, Mourra N, Lefevre JH, Flejou JF, Tiret E, Gespach C, Parc YR. Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer.
Br J Surg. 2007 Apr 17;

Guillem JG, Glogowski E, Moore HG, Nafa K, Markowitz AJ, Shia J, Offit K, Ellis NA. Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg. 2007 Apr;245(4):560-5.

Haug U, Rothenbacher D, Wente MN, Seiler CM, Stegmaier C, Brenner H. Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients. Br J Cancer. 2007 May 7;96(9):1329-34

Wang JY, Lin SR, Wu DC, Lu CY, Yu FJ, Hsieh JS, Cheng TL, Koay LB, Uen YH. Multiple molecular markers as predictors of colo rectal cancer in patients with normal perioperative serum carcinoembryonic antigen levels. Clin Cancer Res. 2007 Apr 15;13(8):2406-13.

Saito N, Kameoka S, Furukawa R. Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncol Rep. 2007 May;17(5):1061-5.

Huang ZH, Li LH, Yang F, Wang JF. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J Gastroenterol. 2007 Feb 14;13(6):950-4.

Popat S, Zhao D, Chen Z, Pan H, Shao Y, Chandler I, Houlston RS.Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients.
Anticancer Res. 2007 Jan-Feb;27(1B):627-33.

Schmidt K, Diehl F. A blood-based DNA test for colorectal cancer screening. Discov Med. 2007 Feb;7(37):7-12.

Hong Y, Ho KS, Eu KW, Cheah PY. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. Clin Cancer Res. 2007 Feb 15;13(4):1107-14.

Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-mediated p53 protein therapy prevents liver metastasis in vivo. Cancer Res. 2007 Feb 15;67(4):1769-74.

Bautista CV, Felis CP, Espinet JM, Garcia JB, Salas JV. Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer. Dis Colon Rectum. 2007 Feb 13;

Kohonen-Corish MR, Sigglekow ND, Susanto J, Chapuis PH, Bokey EL, Dent OF, Chan C, Lin BP, Seng TJ, Laird PW, Young J, Leggett BA, Jass JR, Sutherland RL. Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene. 2007 Jan 29;

Mollevi DG, Serrano T, Ginesta MM, Valls J, Torras J, Navarro M, Ramos E, Germa JR, Jaurrieta E, Moreno V, Figueras J, Capella G, Villanueva A. Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection. Carcinogenesis. 2007 Jan 27;

Gao XQ, Han JX, Xu ZF, Zhang WD, Zhang HN, Huang HY. Identification of the differential expressive tumor associated genes in rectal cancers by cDNA microarray. World J Gastroenterol. 2007 Jan 21;13(3):341-8.

Kim GP, Colangelo LH, Wieand HS, Paik S, Kirsch IR, Wolmark N, Allegra CJ; National Cancer Institute. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol. 2007 Mar 1;25(7):767-72. 

Lu H, Goodell V, Disis ML. Targeting serum antibody for cancer diagnosis: a focus on colorectal cancer. Expert Opin Ther Targets. 2007 Feb;11(2):235-44. Review.

Altomare DF, Rotelli MT, Pentimone A, Rossiello MR, Martinelli E, Guglielmi A, De Fazio M, Marino F, Memeo V, Colucci M, Semeraro N. Tissue factor and vascular endothelial growth factor expression in colorectal cancer: relation with cancer recurrence. Colorectal Dis. 2007 Feb;9(2):133-8.

Martensson A, Oberg A, Jung A, Cederquist K, Stenling R, Palmqvist R. Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep. 2007 Feb;17(2):447-52.

Sadahiro S, Suzuki T, Maeda Y, Yurimoto S, Yasuda S, Makuuchi H, Kamijo A, Murayama C. Detection of Carcinoembryonic Antigen Messenger RNA-Expressing Cells in Peripheral Blood 7 Days After Curative Surgery is a Novel Prognostic Factor in Colorectal Cancer. Ann Surg Oncol. 2007 Mar;14(3):1092-8.

Wallner M, Herbst A, Behrens A, Crispin A, Stieber P, Goke B, Lamerz R, Kolligs FT. Methylation of serum DNA is an independent prognostic marker in colorectal cancer.
Clin Cancer Res. 2006 Dec 15;12(24):7347-52.

Rmali KA, Puntis MC, Jiang WG. Tumour-associated angiogenesis in human colorectal cancer. Colorectal Dis. 2007 Jan;9(1):3-14. Review.

Kurer MA. Protein and mRNA expression of tissue factor pathway inhibitor-1 (TFPI-1) in breast, pancreatic and colorectal cancer cells. Mol Biol Rep. 2006 Dec 19;

Itzkowitz SH, Jandorf L, Brand R, Rabeneck L, Schroy PC 3rd, Sontag S, Johnson D, Skoletsky J, Durkee K, Markowitz S, Shuber A. Improved fecal DNA test for colorectal cancer screening.
Clin Gastroenterol Hepatol. 2007 Jan;5(1):111-7.

Flamini E, Mercatali L, Nanni O, Calistri D, Nunziatini R, Zoli W, Rosetti P, Gardini N, Lattuneddu A, Verdecchia GM, Amadori D. Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer.
Clin Cancer Res. 2006 Dec 1;12(23):6985-8.  

Ragazzi E, Pucciarelli S, Seraglia R, Molin L, Agostini M, Lise M, Traldi P, Nitti D. Multivariate analysis approach to the plasma protein profile of patients with advanced colorectal cancer.
J Mass Spectrom. 2006 Dec;41(12):1546-53.

Allen-Mersh TG, McCullough TK, Patel H, Wharton RQ, Glover C, Jonas SK. Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinoma.
Br J Surg. 2007 Jan;94(1):96-105.

Azzoni C, Bottarelli L, Campanini N, Di Cola G, Bader G, Mazzeo A, Salvemini C, Morari S, Di Mauro D, Donadei E, Roncoroni L, Bordi C, Sarli L. Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. Int J Colorectal Dis. 2007 Feb;22(2):115-26.

Zitt M, Zitt M, Muller HM. DNA methylation in colorectal cancer - Impact on screening and therapy monitoring modalities?
Dis Markers. 2007;23(1-2):51-71.

Chen WC, Lin MS, Zhang BF, Fang J, Zhou Q, Hu Y, Gao HJ. Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. World J Gastroenterol. 2007 Feb 7;13(5):699-708.

Taback B, Saha S, Hoon DS. Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. Ann N Y Acad Sci. 2006 Sep;1075:197-203.

Frattini M, Gallino G, Signoroni S, Balestra D, Battaglia L, Sozzi G, Leo E, Pilotti S, Pierotti MA. Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool.
Ann N Y Acad Sci. 2006 Sep;1075:185-90.   

Chung YC, Chaen YL, Hsu CP. Clinical significance of tissue expression of interleukin-6 in colorectal carcinoma. Anticancer Res. 2006 Sep-Oct;26(5B):3905-11.

Doger FK, Meteoglu I, Tuncyurek P, Okyay P, Cevikel H. Does the EGFR and VEGF expression predict the prognosis in colon cancer? Eur Surg Res. 2006;38(6):540-4.  

Katsumata K, Sumi T, Mori Y, Hisada M, Tsuchida A, Aoki T. Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR. Int J Clin Oncol. 2006 Oct;11(5):385-9. 

Solmi R, Ugolini G, Rosati G, Zanotti S, Lauriola M, Montroni I, del Governatore M, Caira A, Taffurelli M, Santini D, Coppola D, Guidotti L, Carinci P, Strippoli P. Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer. BMC Cancer. 2006 Oct 20;6:250.

Azzoni C, Bottarelli L, Campanini N, Di Cola G, Bader G, Mazzeo A, Salvemini C, Morari S, Di Mauro D, Donadei E, Roncoroni L, Bordi C, Sarli L. Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. Int J Colorectal Dis. 2007 Feb;22(2):115-26. 

Tutton MG, Sharif SP, Eccles SA, George ML, Abulafi AM. Preoperative plasma MMP-2 expression is prognostic in colorectal cancer. Colorectal Dis. 2006 Oct;8(8):722.   

Barrier A, Boelle PY, Roser F, Gregg J, Tse C, Brault D, Lacaine F, Houry S, Huguier M, Franc B, Flahault A, Lemoine A, Dudoit S. Stage II colon cancer prognosis prediction by tumor gene expression profiling. J Clin Oncol. 2006 Oct 10;24(29):4685-91.

Cohen SJ, Alpaugh RK, Gross S, O'Hara SM, Smirnov DA, Terstappen LW, Allard WJ, Bilbee M, Cheng JD, Hoffman JP, Lewis NL, Pellegrino A, Rogatko A, Sigurdson E, Wang H, Watson JC, Weiner LM, Meropol NJ.  Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2006 Jul;6(2):125-32.

Theodoropoulos G, Papaconstantinou I, Felekouras E, Nikiteas N, Karakitsos P, Panoussopoulos D, Lazaris ACh, Patsouris E, Bramis J, Gazouli M. Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.
World J Gastroenterol. 2006 Aug 21;12(31):5037-43.

Hebbar M, Wacrenier A, Desauw C, Romano O, Cattan S, Triboulet JP, Pruvot FR. Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer.
Anticancer Drugs. 2006 Aug;17(7):855-7.

Goode EL, Potter JD, Bamlet WR, Rider DN, Bigler J. Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. Carcinogenesis. 2006 Aug 21;

Halvarsson B, Muller W, Planck M, Benoni AC, Mangell P, Ottosson J, Hallen M, Isinger A, Nilbert M. Phenotypic heterogeneity in hereditary nonpolyposis colorectal cancer: identical germline mutations associated with variable tumor morphology and immunohistochemical expression.
J Clin Pathol. 2006 Aug 10;

Di Gregorio C, Frattini M, Maffei S, Ponti G, Losi L, Pedroni M, Venesio T, Bertario L, Varesco L, Risio M, Ponz de Leon M. Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis.
Gastroenterology. 2006 Aug;131(2):439-44.

Elzagheid A, Algars A, Bendardaf R, Lamlum H, Ristamaki R, Collan Y, Syrjanen K, Pyrhonen S. E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol. 2006 Jul 21;12(27):4304-9.

Bandres E, Cubedo E, Agirre X, Malumbres R, Zarate R, Ramirez N, Abajo A, Navarro A, Moreno I, Monzo M, Garcia-Foncillas J. Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer. 2006 Jul 19;5:29.

Swede H, Bartos JD, Chen N, Shaukat A, Dutt SS, McQuaid DA, Natarajan N, Rodriguez-Bigas MA, Nowak NJ, Wiseman SM, Alrawi S, Brenner BM, Petrelli NJ, Cummings KM, Stoler DL, Anderson GR. Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet. 2006 Jul 15;168(2):98-104.

Kim JS, Kim JM, Li S, Yoon WH, Song KS, Kim KH, Yeo SG, Nam JS, Cho MJ. Epidermal growth factor receptor as a predictor of tumor downstaging in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy.
Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):195-200.

Murphy KM, Zhang S, Geiger T, Hafez MJ, Bacher J, Berg KD, Eshleman JR. Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers.
J Mol Diagn. 2006 Jul;8(3):305-11.

Polley AC, Mulholland F, Pin C, Williams EA, Bradburn DM, Mills SJ, Mathers JC, Johnson IT. Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia.
Cancer Res. 2006 Jul 1;66(13):6553-62.

Skjelbred CF, Saebo M, Nexo BA, Wallin H, Hansteen IL, Vogel U, Kure EH. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.
BMC Cancer. 2006 Jul 3;6:175.

Holten-Andersen MN, Nielsen HJ, Sorensen S, Jensen V, Brunner N, Christensen IJ. Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer.
Eur J Cancer. 2006 Aug;42(12):1889-96.

Bortlik M, Vitkova I, Papezova M, Kohoutova M, Novotny A, Adamec S, Chalupna P, Lukas M. Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology.
World J Gastroenterol. 2006 Jun 28;12(24):3901-5.

Kanellos I, Zacharakis E, Kanellos D, Pramateftakis MG, Tsahalis T, Altsitsiadis E, Betsis D. Prognostic significance of CEA levels and detection of CEA mRNA in draining venous blood in patients with colorectal cancer. J Surg Oncol. 2006 Jul 1;94(1):3-8.

Zhang W, Gordon M, Press OA, Rhodes K, Vallbohmer D, Yang DY, Park D, Fazzone W, Schultheis A, Sherrod AE, Iqbal S, Groshen S, Lenz HJ. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab.
Pharmacogenet Genomics. 2006 Jul;16(7):475-83.

Trusky CL, Sepulveda AR, Hunt JL. Assessment of microsatellite instability in very small microdissected samples and in tumor samples that are contaminated with normal DNA.
Diagn Mol Pathol. 2006 Jun;15(2):63-9.

Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1126-31.

Zou H, Harrington JJ, Klatt KK, Ahlquist DA.A sensitive method to quantify human long DNA in stool: relevance to colorectal cancer screening. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1115-9.

Peterlongo P, Mitra N, de Abajo AS, de la Hoya M, Bassi C, Bertario L, Radice P, Glogowski E, Nafa K, Caldes T, Offit K, Ellis NA. Increased frequency of disease-causing MYH mutations in colon cancer families.
Carcinogenesis. 2006 Jun 14;

Bianchini M, Levy E, Zucchini C, Pinski V, Macagno C, De Sanctis P, Valvassori L, Carinci P, Mordoh J. Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa. Int J Oncol. 2006 Jul;29(1):83-94.

Des Guetz G, Uzzan B, Nicolas P, Cucherat M, Morere JF, Benamouzig R, Breau JL, Perret GY. Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature. Br J Cancer. 2006 Jun 19;94(12):1823-32.

Shioiri M, Shida T, Koda K, Oda K, Seike K, Nishimura M, Takano S, Miyazaki M. Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.
Br J Cancer. 2006 Jun 19;94(12):1816-22.

Ohlsson L, Hammarstrom ML, Israelsson A, Naslund L, Oberg A, Lindmark G, Hammarstrom S. Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR.
Br J Cancer. 2006 Jul 17;95(2):218-25

Wang JY, Wu CH, Lu CY, Hsieh JS, Wu DC, Huang SY, Lin SR. Molecular detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer using RT-PCR: significance of the prediction of postoperative metastasis.
World J Surg. 2006 Jun;30(6):1007-13.  

Madoz-Gurpide J, Lopez-Serra P, Martinez-Torrecuadrada JL, Sanchez L, Lombardia L, Casal JI. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.
Mol Cell Proteomics. 2006 Aug;5(8):1471-83.

Huang CC, Cheng YW, Chen MC, Lin YS, Chou MC, Lee H. Different p53 mutation patterns in colorectal tumors from smokers and nonsmokers. Environ Mol Mutagen. 2006 Aug;47(7):527-32.

Xu D, Li XF, Zheng S, Jiang WZ. Quantitative real-time RT-PCR detection for CEA, CK20 and CK19 mRNA in peripheral blood of colorectal cancer patients. J Zhejiang Univ Sci B. 2006 Jun;7(6):445-51.

Bi X, Lin Q, Foo TW, Joshi S, You T, Shen HM, Ong CN, Cheah PY, Eu KW, Hew CL. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.
Mol Cell Proteomics. 2006 Jun;5(6):1119-30.

Francoual M, Etienne-Grimaldi MC, Formento JL, Benchimol D, Bourgeon A, Chazal M, Letoublon C, Andre T, Gilly N, Delpero JR, Lasser P, Spano JP, Milano G. EGFR in colorectal cancer: more than a simple receptor. Ann Oncol. 2006 Jun;17(6):962-7.

Funaioli C, Pinto C, Mutri V, Fabio FD, Ceccarelli C, Martoni AA. Does Biomolecular Characterization of Stage II/III Colorectal Cancer Have Any Prognostic Value? Clin Colorectal Cancer. 2006 May;6(1):38-45.

Gibson TB, Ranganathan A, Grothey A. Randomized Phase III Trial Results of Panitumumab, a Fully Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody, in Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2006 May;6(1):29-31.

De Bruin JH, Ligtenberg MJ, Nagengast FM, Adang EM, Van Krieken JH, Hoogerbrugge N. Optimizing the detection of hereditary non-polyposis colorectal cancer: An update.
Scand J Gastroenterol Suppl. 2006 May;(243):146-52.

Mamot C, Ritschard R, Kung W, Park JW, Herrmann R, Rochlitz CF. EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells.
J Drug Target. 2006 May;14(4):215-23.

Madoz-Gurpide J, Lopez-Serra P, Martinez-Torrecuadrada JL, Sanchez L, Lombardia L, Casal JI. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.
Mol Cell Proteomics. 2006 May 29;

Lamberti C, Lundin S, Bogdanow M, Pagenstecher C, Friedrichs N, Buttner R, Sauerbruch T. Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer. Int J Colorectal Dis. 2006 May 25;

Lanza G, Gafa R, Santini A, Maestri I, Guerzoni L, Cavazzini L. Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients.
J Clin Oncol. 2006 May 20;24(15):2359-67.  

Wang JY, Wu CH, Lu CY, Hsieh JS, Wu DC, Huang SY, Lin SR. Molecular Detection of Circulating Tumor Cells in the Peripheral Blood of Patients with Colorectal Cancer Using RT-PCR: Significance of the Prediction of Postoperative Metastasis.
World J Surg. 2006 May 4;

Tsai WS, Changchien CR, Yeh CY, Chen JS, Tang R, Chiang JM, Hsieh PS, Fan CW, Wang JY. Preoperative Plasma Vascular Endothelial Growth Factor But Not Nitrite Is a Useful Complementary Tumor Marker in Patients With Colorectal Cancer.
Dis Colon Rectum. 2006 Apr 28;

Sugai T, Habano W, Jiao YF, Tsukahara M, Takeda Y, Otsuka K, Nakamura S. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn. 2006 May;8(2):193-201.

Douard R, Wind P, Sales JP, Landi B, Berger A, Benichou J, Gayral F, Loric S, Cugnenc PH. Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.
Surgery. 2006 Apr;139(4):556-62.

Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Cote JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
Cancer Res. 2006 Apr 15;66(8):3992-5.

Watanabe T, Komuro Y, Kiyomatsu T, Kanazawa T, Kazama Y, Tanaka J, Tanaka T, Yamamoto Y, Shirane M, Muto T, Nagawa H. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Cancer Res. 2006 Apr 1;66(7):3370-4.

Francoual M, Etienne-Grimaldi MC, Formento JL, Benchimol D, Bourgeon A, Chazal M, Letoublon C, Andre T, Gilly N, Delpero JR, Lasser P, Spano JP, Milano G. EGFR in colorectal cancer: more than a simple receptor. Ann Oncol. 2006 Jun;17(6):962-7.

Wu X, Wan M, Li G, Xu Z, Chen C, Liu F, Li J. Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy. Eur J Cancer. 2006 May;42(7):888-94.

Xi L, Gooding W, McCarty K, Godfrey TE, Hughes SJ. Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer. Clin Chem. 2006 Mar;52(3):520-3.

Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. The colorectal microRNAome. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92.

Xu WH, Chen YD, Hu Y, Yu JK, Wu XG, Jiang TJ, Zheng S, Zhang SZ. Preoperatively molecular staging with CM10 ProteinChip and SELDI-TOF-MS for colorectal cancer patients.
J Zhejiang Univ Sci B. 2006 Mar;7(3):235-40.

Ellmark P, Belov L, Huang P, Lee CS, Solomon MJ, Morgan DK, Christopherson RI. Multiplex detection of surface molecules on colorectal cancers. Proteomics. 2006 Mar;6(6):1791-802.

Bustin SA, Mueller R. Real-time reverse transcription PCR and the detection of occult disease in colorectal cancer.
Mol Aspects Med. 2006 Apr-Jun;27(2-3):192-223.

Chang SC, Lin JK, Yang SH, Wang HS, Li AF, Chi CW. Relationship between genetic alterations and prognosis in sporadic colorectal cancer. Int J Cancer. 2006 Apr 1;118(7):1721-7.

Deschoolmeester V, Baay M, Wuyts W, Marck EV, Pelckmans P, Lardon F, Vermorken JB. Comparison of three commonly used PCR-based techniques to analyze MSI status in sporadic colorectal cancer. J Clin Lab Anal. 2006;20(2):52-61.  

Sebzda T, Saleh Y, Gburek J, Warwas M, Andrzejak R, Siewinski M, Rudnicki J. Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.
J Exp Ther Oncol. 2006;5(3):223-9.  

Berger BM, Schroy PC 3rd, Rosenberg JL, Lai-Goldman M, Eisenberg M, Brown T, Rochelle RB, Billings PR. Colorectal cancer screening using stool DNA analysis in clinical practice: early clinical experience with respect to patient acceptance and colonoscopic follow-up of abnormal tests. Clin Colorectal Cancer. 2006 Jan;5(5):338-43. 

Vincenzi B, Santini D, Russo A, Silletta M, Gavasci M, Battistoni F, Di Cuonzo G, Rocci L, Gebbia N, Tonini G. Angiogenesis modifications related with cetuximab plus irinotecan as anticancer treatment in advanced colorectal cancer patients.
Ann Oncol. 2006 Feb 28;  

Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE. The colorectal microRNAome. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3687-92. 

Hibi K, Nakao A. Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer. Anticancer Res. 2006 Jan-Feb;26(1A):55-8. 

Yoon SS, Kim SH, Gonen M, Heffernan NM, Detwiller KY, Jarnagin WR, D'Angelica M, Blumgart LH, Tanabe KK, Dematteo RP. Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. Ann Surg Oncol. 2006 Mar;13(3):353-62.  

Shiono S, Ishii G, Nagai K, Murata Y, Tsuta K, Nitadori J, Kodama T, Ochiai A. Immunohistochemical prognostic factors in resected colorectal lung metastases using tissue microarray analysis.
Eur J Surg Oncol. 2006 Apr;32(3):308-9.  

Fraser CG, Matthew CM, Mowat NA, Wilson JA, Carey FA, Steele RJ. Immunochemical testing of individuals positive for guaiac faecal occult blood test in a screening programme for colorectal cancer: an observational study. Lancet Oncol. 2006 Feb;7(2):127-31. 

Giribaldi G, Procida S, Ulliers D, Mannu F, Volpatto R, Mandili G, Fanchini L, Bertetto O, Fronda G, Simula L, Rimini E, Cherchi G, Bonello L, Maule MM, Turrini F. Specific detection of cytokeratin 20-positive cells in blood of colorectal and breast cancer patients by a high sensitivity real-time reverse transcriptase-polymerase chain reaction method. J Mol Diagn. 2006 Feb;8(1):105-12.  

Chialina SG, Fornes C, Landi C, de la Vega Elena CD, Nicolorich MV, Dourisboure RJ, Solano A, Solis EA. Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue. BMC Med Genet. 2006 Jan 20;7:5. 

Famulski W, Sulkowska M, Wincewicz A, Kedra B, Pawlak K, Zalewski B, Sulkowski S, Koda M, Baltaziak M.  P53 correlates positively with VEGF in preoperative sera of colorectal cancer patients. Neoplasma. 2006;53(1):43-8.  

Iinuma H, Okinaga K, Egami H, Mimori K, Hayashi N, Nishida K, Adachi M, Mori M, Sasako M. Usefulness and clinical significance of quantitative real-time RT-PCR to detect isolated tumor cells in the peripheral blood and tumor drainage blood of patients with colorectal cancer. Int J Oncol. 2006 Feb;28(2):297-306.  

Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS. The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8564-9.  

Gordon MA, Gil J, Lu B, Zhang W, Yang D, Yun J, Schneider S, Groshen S, Iqbal S, Press OA, Rhodes K, Lenz HJ. Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics. 2006 Jan;7(1):67-88. 

Syngal S, Stoffel E, Chung D, Willett C, Schoetz D, Schroy P, Jagadeesh D, Morel K, Ross M. Detection of stool DNA mutations before and after treatment of colorectal neoplasia. Cancer. 2006 Jan 15;106(2):277-83. 

Benatti P, Gafa R, Barana D, Marino M, Scarselli A, Pedroni M, Maestri I, Guerzoni L, Roncucci L, Menigatti M, Roncari B, Maffei S, Rossi G, Ponti G, Santini A, Losi L, Di Gregorio C, Oliani C, Ponz de Leon M, Lanza G. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res. 2005 Dec 1;11(23):8332-40.  

Duff SE, Jeziorska M, Rosa DD, Kumar S, Haboubi N, Sherlock D, O'Dwyer ST, Jayson GC. Vascular endothelial growth factors and receptors in colorectal cancer: implications for anti-angiogenic therapy. Eur J Cancer. 2006 Jan;42(1):112-7.  

Sadahiro S, Suzuki T, Ishikawa K, Saguchi T, Maeda Y, Yasuda S, Makuuchi H, Yurimoto S, Murayama C. Detection of carcinoembryonic antigen messenger RNA-expressing cells in portal and peripheral blood during surgery does not influence relapse in colorectal cancer. Ann Surg Oncol. 2005 Dec;12(12):988-94. 

Barrier A, Boelle PY, Lemoine A, Tse C, Brault D, Chiappini F, Lacaine F, Houry S, Huguier M, Flahault A, Dudoit S. Gene expression profiling of nonneoplastic mucosa may predict clinical outcome of colon cancer patients. Dis Colon Rectum. 2005 Dec;48(12):2238-48. 

Zlobec I, Steele R, Compton CC. VEGF as a predictive marker of rectal tumor response to preoperative radiotherapy. Cancer. 2005 Dec 1;104(11):2517-21.

Ward RL, Turner J, Williams R, Pekarsky B, Packham D, Velickovic M, Meagher A, O'Connor T, Hawkins NJ. Routine testing for mismatch repair deficiency in sporadic colorecl cancer is justified. J Pathol. 2005 Dec;207(4):377-84.  

Engel C, Forberg J, Holinski-Feder E, Pagenstecher C, Plaschke J, Kloor M, Poremba C, Pox CP, Ruschoff J, Keller G, Dietmaier W, Rummele P, Friedrichs N, Mangold E, Buettner R, Schackert HK, Kienle P, Stemmler S, Moeslein G, Loeffler M; German HNPCC Consortium. Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer.
Int J Cancer. 2006 Jan 1;118(1):115-22

Jover R, Zapater P, Castells A, Llor X, Andreu M, Cubiella J, Pinol V, Xicola RM, Bujanda L, Rene JM, Clofent J, Bessa X, Morillas JD, Nicolas-Perez D, Paya A, Alenda C. Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy on colorectal cancer. Gut. 2005 Nov 18;   

Camps J, Armengol G, Del Rey J, Lozano J, Vauhkonen H, Prat E, Egozcue J, Sumoy L, Knuutila S, Miro R. Genome-wide differences between microsatellite stable and unstable colorectal tumors. Carcinogenesis. 2005 Nov 4; 

Dandachi N, Balic M, Stanzer S, Halm M, Resel M, Hinterleitner TA, Samonigg H, Bauernhofer T. Critical evaluation of real-time reverse transcriptase-polymerase chain reaction for the quantitative detection of cytokeratin 20 mRNA in colorectal cancer patients. J Mol Diagn. 2005 Nov;7(5):631-7.  

Diehl F, Li M, Dressman D, He Y, Shen D, Szabo S, Diaz LA Jr, Goodman SN, David KA, Juhl H, Kinzler KW, Vogelstein B. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16368-73.

Sanz-Casla MT, Vidaurreta M, Sanchez-Rueda D, Maestro ML, Arroyo M, Cerdan FJ. Telomerase activity as a prognostic factor in colorectal cancer. Onkologie. 2005 Nov;28(11):553-7.  

Sadahiro S, Suzuki T, Ishikawa K, Saguchi T, Maeda Y, Yasuda S, Makuuchi H, Yurimoto S, Murayama C. Detection of carcinoembryonic antigen messenger RNA-expressing cells in portal and peripheral blood during surgery does not influence relapse in colorectal cancer. Ann Surg Oncol. 2005 Dec;12(12):988-94.