- Click on the title of each paper to access MedLine abstract at NLM site
Molecular biology and colorectal cancer markers

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Onouchi S, Matsushita H, Moriya Y, Akasu T, Fujita S, Yamamoto S, Hasegawa H, Kitagawa Y, Matsumura Y. New method for colorectal cancer diagnosis based on SSCP analysis of DNA from exfoliated colonocytes in naturally evacuated feces. Anticancer Res. 2008 Jan-Feb;28(1A):145-50.

Chan SK, Griffith OL, Tai IT, Jones SJ. Meta-analysis of Colorectal Cancer Gene Expression Profiling Studies Identifies Consistently Reported Candidate Biomarkers. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):543-52.

Ferreira S, Claro I, Lage P, Filipe B, Fonseca R, Sousa R, Francisco I, Chaves P, Albuquerque C, Leitão CN. Colorectal Adenomas in Young Patients: Microsatellite Instability is not a Useful Marker to Detect New Cases of Lynch Syndrome. Dis Colon Rectum. 2008 Feb 29;

Yoshiya G, Takahata T, Hanada N, Suzuki K, Ishiguro A, Saito M, Sasaki M, Fukuda S. Influence of cancer-related gene polymorphisms on clinicopathological features in colorectal cancer. J Gastroenterol Hepatol. 2008 Jan 17;

Han M, Liew CT, Zhang HW, Chao S, Zheng R, Yip KT, Song ZY, Li HM, Geng XP, Zhu LX, Lin JJ, Marshall KW, Liew CC. Novel blood-based, five-gene biomarker set for the detection of colorectal cancer. Clin Cancer Res. 2008 Jan 15;14(2):455-60.

Rimkus C, Friederichs J, Boulesteix AL, Theisen J, Mages J, Becker K, Nekarda H, Rosenberg R, Janssen KP, Siewert JR. Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer. Clin Gastroenterol Hepatol. 2008 Jan;6(1):53-61.

Rimkus C, Friederichs J, Boulesteix AL, Theisen J, Mages J, Becker K, Nekarda H, Rosenberg R, Janssen KP, Siewert JR. Microarray-based prediction of tumor response to neoadjuvant radiochemotherapy of patients with locally advanced rectal cancer. Clin Gastroenterol Hepatol. 2008 Jan;6(1):53-61.

Zlobec I, Minoo P, Baumhoer D, Baker K, Terracciano L, Jass JR, Lugli A. Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. Cancer. 2008 Feb 1;112(3):495-502.

Abd El All HS, Mishriky AM, Mohamed FA. Epidermal growth factor receptor in colorectal carcinoma: correlation with clinico-pathological prognostic factors. Colorectal Dis. 2008 Feb;10(2):170-8

Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA. VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol. 2008 Mar;15(3):738-44. Epub 2007 Nov 28.

Meng WJ, Sun XF, Tian C, Wang L, Yu YY, Zhou B, Gu J, Xia QJ, Li Y, Wang R, Zheng XL, Zhou ZG. Microsatellite instability did not predict individual survival in sporadic stage II and III rectal cancer patients. Oncology. 2007;72(1-2):82-8. Epub 2007 Nov 14.

Ponz-Sarvisé M, Rodríguez J, Viudez A, Chopitea A, Calvo A, García-Foncillas J, Gil-Bazo I.  Epidermal growth factor receptor inhibitors in colorectal cancer treatment: what's new? World J Gastroenterol. 2007 Nov 28;13(44):5877-87. Review.

Simiantonaki N, Taxeidis M, Jayasinghe C, Kirkpatrick CJ. Epithelial expression of VEGF receptors in colorectal carcinomas and their relationship to metastatic status. Anticancer Res. 2007 Sep-Oct;27(5A):3245-50.

de Heer P, de Bruin EC, Klein-Kranenbarg E, Aalbers RI, Marijnen CA, Putter H, de Bont HJ, Nagelkerke JF, van Krieken JH, Verspaget HW, van de Velde CJ, Kuppen PJ; Dutch Colorectal Cancer Group. Caspase-3 activity predicts local recurrence in rectal cancer. Clin Cancer Res. 2007 Oct 1;13(19):5810-5.

Li M, Li JY, Zhao AL, He JS, Zhou LX, Li YA, Gu J.  Survival stratification panel of colorectal carcinoma with combined expression of carcinoembryonic antigen, matrix metalloproteinases-2, and p27 kip1. Dis Colon Rectum. 2007 Nov;50(11):1887-98.

Araujo SE, Bernardo WM, Habr-Gama A, Kiss DR, Cecconello I.  DNA ploidy status and prognosis in colorectal cancer: a meta-analysis of published data. Dis Colon Rectum. 2007 Nov;50(11):1800-10. Review.

Xu F, Wang F, Di M, Huang Q, Wang M, Hu H, Jin Y, Dong J, Lai M. Classification based on the combination of molecular and pathologic predictors is superior to molecular classification on prognosis in colorectal carcinoma. Clin Cancer Res. 2007 Sep 1;13(17):5082-8.  

Bendardaf R, Lamlum H, Ristamaki R, Korkeila E, Syrjanen K, Pyrhonen S. Mismatch repair status is a predictive factor of tumour response to 5-fluorouracil and irinotecan chemotherapy in patients with advanced colorectal cancer. Tumour Biol. 2007;28(4):212-20. Epub 2007 Aug 24.  

Iddings DM, Koda EA, Grewal SS, Parker R, Saha S, Bilchik A. Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Arch Surg. 2007 Aug;142(8):738-44; discussion 744-5.  

Xi Y, Nakajima G, Gavin E, Morris CG, Kudo K, Hayashi K, Ju J. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA. 2007 Oct;13(10):1668-74.  

Kelder W, Braat A, van den Berg A, Platteel I, Hollema H, Groen H, Plukker J. Value of RT-PCR analysis of sentinel nodes in determining the pathological nodal status in colon cancer. Anticancer Res. 2007 Jul-Aug;27(4C):2855-9.

Zafirellis K, Agrogiannis G, Zachaki A, Gravani K, Karameris A, Kombouras C. Prognostic Significance of VEGF Expression Evaluated by Quantitative Immunohistochemical Analysis in Colorectal Cancer.
J Surg Res. 2007 Jul 25;

Ferroni P, Palmirotta R, Spila A, Martini F, Formica V, Portarena I, Del Monte G, Buonomo O, Roselli M, Guadagni F. Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer.
Oncology. 2006;71(3-4):176-84.

Collins VR, Meiser B, Ukoumunne OC, Gaff C, St John DJ, Halliday JL. The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing. Genet Med. 2007 May;9(5):290-297.

Hara M, Nakanishi H, Jun Q, Kanemitsu Y, Ito S, Mochizuki Y, Yamamura Y, Kodera Y, Tatematsu M, Hirai T, Kato T. Comparative analysis of intraperitoneal minimal free cancer cells between colorectal and gastric cancer patients using quantitative RT-PCR: possible reason for rare peritoneal recurrence in colorectal cancer.
Clin Exp Metastasis. 2007;24(3):179-89.

Zumkeller N, Brenner H, Chang-Claude J, Hoffmeister M, Nieters A, Rothenbacher D. Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: Evidence from a case-control study in Germany. Eur J Cancer. 2007 May;43(8):1283-9.

Ewald J, Rodrigue CM, Mourra N, Lefevre JH, Flejou JF, Tiret E, Gespach C, Parc YR. Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer.
Br J Surg. 2007 Apr 17;

Guillem JG, Glogowski E, Moore HG, Nafa K, Markowitz AJ, Shia J, Offit K, Ellis NA. Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. Ann Surg. 2007 Apr;245(4):560-5.

Haug U, Rothenbacher D, Wente MN, Seiler CM, Stegmaier C, Brenner H. Tumour M2-PK as a stool marker for colorectal cancer: comparative analysis in a large sample of unselected older adults vs colorectal cancer patients. Br J Cancer. 2007 May 7;96(9):1329-34

Wang JY, Lin SR, Wu DC, Lu CY, Yu FJ, Hsieh JS, Cheng TL, Koay LB, Uen YH. Multiple molecular markers as predictors of colo rectal cancer in patients with normal perioperative serum carcinoembryonic antigen levels. Clin Cancer Res. 2007 Apr 15;13(8):2406-13.

Saito N, Kameoka S, Furukawa R. Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncol Rep. 2007 May;17(5):1061-5.

Huang ZH, Li LH, Yang F, Wang JF. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J Gastroenterol. 2007 Feb 14;13(6):950-4.

Popat S, Zhao D, Chen Z, Pan H, Shao Y, Chandler I, Houlston RS.Relationship between chromosome 18q status and colorectal cancer prognosis: a prospective, blinded analysis of 280 patients.
Anticancer Res. 2007 Jan-Feb;27(1B):627-33.

Schmidt K, Diehl F. A blood-based DNA test for colorectal cancer screening. Discov Med. 2007 Feb;7(37):7-12.

Hong Y, Ho KS, Eu KW, Cheah PY. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. Clin Cancer Res. 2007 Feb 15;13(4):1107-14.

Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, Reeves ME. Antibody-mediated p53 protein therapy prevents liver metastasis in vivo. Cancer Res. 2007 Feb 15;67(4):1769-74.

Bautista CV, Felis CP, Espinet JM, Garcia JB, Salas JV. Telomerase Activity is a Prognostic Factor for Recurrence and Survival in Rectal Cancer. Dis Colon Rectum. 2007 Feb 13;

Kohonen-Corish MR, Sigglekow ND, Susanto J, Chapuis PH, Bokey EL, Dent OF, Chan C, Lin BP, Seng TJ, Laird PW, Young J, Leggett BA, Jass JR, Sutherland RL. Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene. 2007 Jan 29;

Mollevi DG, Serrano T, Ginesta MM, Valls J, Torras J, Navarro M, Ramos E, Germa JR, Jaurrieta E, Moreno V, Figueras J, Capella G, Villanueva A. Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection. Carcinogenesis. 2007 Jan 27;

Gao XQ, Han JX, Xu ZF, Zhang WD, Zhang HN, Huang HY. Identification of the differential expressive tumor associated genes in rectal cancers by cDNA microarray. World J Gastroenterol. 2007 Jan 21;13(3):341-8.

Kim GP, Colangelo LH, Wieand HS, Paik S, Kirsch IR, Wolmark N, Allegra CJ; National Cancer Institute. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study. J Clin Oncol. 2007 Mar 1;25(7):767-72. 

Lu H, Goodell V, Disis ML. Targeting serum antibody for cancer diagnosis: a focus on colorectal cancer. Expert Opin Ther Targets. 2007 Feb;11(2):235-44. Review.

Altomare DF, Rotelli MT, Pentimone A, Rossiello MR, Martinelli E, Guglielmi A, De Fazio M, Marino F, Memeo V, Colucci M, Semeraro N. Tissue factor and vascular endothelial growth factor expression in colorectal cancer: relation with cancer recurrence. Colorectal Dis. 2007 Feb;9(2):133-8.

Martensson A, Oberg A, Jung A, Cederquist K, Stenling R, Palmqvist R. Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep. 2007 Feb;17(2):447-52.

Sadahiro S, Suzuki T, Maeda Y, Yurimoto S, Yasuda S, Makuuchi H, Kamijo A, Murayama C. Detection of Carcinoembryonic Antigen Messenger RNA-Expressing Cells in Peripheral Blood 7 Days After Curative Surgery is a Novel Prognostic Factor in Colorectal Cancer. Ann Surg Oncol. 2007 Mar;14(3):1092-8.

Wallner M, Herbst A, Behrens A, Crispin A, Stieber P, Goke B, Lamerz R, Kolligs FT. Methylation of serum DNA is an independent prognostic marker in colorectal cancer.
Clin Cancer Res. 2006 Dec 15;12(24):7347-52.

Rmali KA, Puntis MC, Jiang WG. Tumour-associated angiogenesis in human colorectal cancer. Colorectal Dis. 2007 Jan;9(1):3-14. Review.

Kurer MA. Protein and mRNA expression of tissue factor pathway inhibitor-1 (TFPI-1) in breast, pancreatic and colorectal cancer cells. Mol Biol Rep. 2006 Dec 19;

Itzkowitz SH, Jandorf L, Brand R, Rabeneck L, Schroy PC 3rd, Sontag S, Johnson D, Skoletsky J, Durkee K, Markowitz S, Shuber A. Improved fecal DNA test for colorectal cancer screening.
Clin Gastroenterol Hepatol. 2007 Jan;5(1):111-7.

Flamini E, Mercatali L, Nanni O, Calistri D, Nunziatini R, Zoli W, Rosetti P, Gardini N, Lattuneddu A, Verdecchia GM, Amadori D. Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer.
Clin Cancer Res. 2006 Dec 1;12(23):6985-8.  

Ragazzi E, Pucciarelli S, Seraglia R, Molin L, Agostini M, Lise M, Traldi P, Nitti D. Multivariate analysis approach to the plasma protein profile of patients with advanced colorectal cancer.
J Mass Spectrom. 2006 Dec;41(12):1546-53.

Allen-Mersh TG, McCullough TK, Patel H, Wharton RQ, Glover C, Jonas SK. Role of circulating tumour cells in predicting recurrence after excision of primary colorectal carcinoma.
Br J Surg. 2007 Jan;94(1):96-105.

Azzoni C, Bottarelli L, Campanini N, Di Cola G, Bader G, Mazzeo A, Salvemini C, Morari S, Di Mauro D, Donadei E, Roncoroni L, Bordi C, Sarli L. Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. Int J Colorectal Dis. 2007 Feb;22(2):115-26.

Zitt M, Zitt M, Muller HM. DNA methylation in colorectal cancer - Impact on screening and therapy monitoring modalities?
Dis Markers. 2007;23(1-2):51-71.

Chen WC, Lin MS, Zhang BF, Fang J, Zhou Q, Hu Y, Gao HJ. Survey of molecular profiling during human colon cancer development and progression by immunohistochemical staining on tissue microarray. World J Gastroenterol. 2007 Feb 7;13(5):699-708.

Taback B, Saha S, Hoon DS. Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. Ann N Y Acad Sci. 2006 Sep;1075:197-203.

Frattini M, Gallino G, Signoroni S, Balestra D, Battaglia L, Sozzi G, Leo E, Pilotti S, Pierotti MA. Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool.
Ann N Y Acad Sci. 2006 Sep;1075:185-90.   

Chung YC, Chaen YL, Hsu CP. Clinical significance of tissue expression of interleukin-6 in colorectal carcinoma. Anticancer Res. 2006 Sep-Oct;26(5B):3905-11.

Doger FK, Meteoglu I, Tuncyurek P, Okyay P, Cevikel H. Does the EGFR and VEGF expression predict the prognosis in colon cancer? Eur Surg Res. 2006;38(6):540-4.  

Katsumata K, Sumi T, Mori Y, Hisada M, Tsuchida A, Aoki T. Detection and evaluation of epithelial cells in the blood of colon cancer patients using RT-PCR. Int J Clin Oncol. 2006 Oct;11(5):385-9. 

Solmi R, Ugolini G, Rosati G, Zanotti S, Lauriola M, Montroni I, del Governatore M, Caira A, Taffurelli M, Santini D, Coppola D, Guidotti L, Carinci P, Strippoli P. Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer. BMC Cancer. 2006 Oct 20;6:250.

Azzoni C, Bottarelli L, Campanini N, Di Cola G, Bader G, Mazzeo A, Salvemini C, Morari S, Di Mauro D, Donadei E, Roncoroni L, Bordi C, Sarli L. Distinct molecular patterns based on proximal and distal sporadic colorectal cancer: arguments for different mechanisms in the tumorigenesis. Int J Colorectal Dis. 2007 Feb;22(2):115-26. 

Tutton MG, Sharif SP, Eccles SA, George ML, Abulafi AM. Preoperative plasma MMP-2 expression is prognostic in colorectal cancer. Colorectal Dis. 2006 Oct;8(8):722.   

Barrier A, Boelle PY, Roser F, Gregg J, Tse C, Brault D, Lacaine F, Houry S, Huguier M, Franc B, Flahault A, Lemoine A, Dudoit S. Stage II colon cancer prognosis prediction by tumor gene expression profiling. J Clin Oncol. 2006 Oct 10;24(29):4685-91.

Cohen SJ, Alpaugh RK, Gross S, O'Hara SM, Smirnov DA, Terstappen LW, Allard WJ, Bilbee M, Cheng JD, Hoffman JP, Lewis NL, Pellegrino A, Rogatko A, Sigurdson E, Wang H, Watson JC, Weiner LM, Meropol NJ.  Isolation and characterization of circulating tumor cells in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2006 Jul;6(2):125-32.

Theodoropoulos G, Papaconstantinou I, Felekouras E, Nikiteas N, Karakitsos P, Panoussopoulos D, Lazaris ACh, Patsouris E, Bramis J, Gazouli M. Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.
World J Gastroenterol. 2006 Aug 21;12(31):5037-43.

Hebbar M, Wacrenier A, Desauw C, Romano O, Cattan S, Triboulet JP, Pruvot FR. Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer.
Anticancer Drugs. 2006 Aug;17(7):855-7.

Goode EL, Potter JD, Bamlet WR, Rider DN, Bigler J. Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps. Carcinogenesis. 2006 Aug 21;

Halvarsson B, Muller W, Planck M, Benoni AC, Mangell P, Ottosson J, Hallen M, Isinger A, Nilbert M. Phenotypic heterogeneity in hereditary nonpolyposis colorectal cancer: identical germline mutations associated with variable tumor morphology and immunohistochemical expression.
J Clin Pathol. 2006 Aug 10;

Di Gregorio C, Frattini M, Maffei S, Ponti G, Losi L, Pedroni M, Venesio T, Bertario L, Varesco L, Risio M, Ponz de Leon M. Immunohistochemical expression of MYH protein can be used to identify patients with MYH-associated polyposis.
Gastroenterology. 2006 Aug;131(2):439-44.

Elzagheid A, Algars A, Bendardaf R, Lamlum H, Ristamaki R, Collan Y, Syrjanen K, Pyrhonen S. E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol. 2006 Jul 21;12(27):4304-9.

Bandres E, Cubedo E, Agirre X, Malumbres R, Zarate R, Ramirez N, Abajo A, Navarro A, Moreno I, Monzo M, Garcia-Foncillas J. Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer. 2006 Jul 19;5:29.

Swede H, Bartos JD, Chen N, Shaukat A, Dutt SS, McQuaid DA, Natarajan N, Rodriguez-Bigas MA, Nowak NJ, Wiseman SM, Alrawi S, Brenner BM, Petrelli NJ, Cummings KM, Stoler DL, Anderson GR. Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet. 2006 Jul 15;168(2):98-104.

Kim JS, Kim JM, Li S, Yoon WH, Song KS, Kim KH, Yeo SG, Nam JS, Cho MJ. Epidermal growth factor receptor as a predictor of tumor downstaging in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy.
Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):195-200.

Murphy KM, Zhang S, Geiger T, Hafez MJ, Bacher J, Berg KD, Eshleman JR. Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers.
J Mol Diagn. 2006 Jul;8(3):305-11.

Polley AC, Mulholland F, Pin C, Williams EA, Bradburn DM, Mills SJ, Mathers JC, Johnson IT. Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasia.
Cancer Res. 2006 Jul 1;66(13):6553-62.

Skjelbred CF, Saebo M, Nexo BA, Wallin H, Hansteen IL, Vogel U, Kure EH. Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.
BMC Cancer. 2006 Jul 3;6:175.

Holten-Andersen MN, Nielsen HJ, Sorensen S, Jensen V, Brunner N, Christensen IJ. Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer.
Eur J Cancer. 2006 Aug;42(12):1889-96.

Bortlik M, Vitkova I, Papezova M, Kohoutova M, Novotny A, Adamec S, Chalupna P, Lukas M. Deficiency of Adenomatous Polyposis Coli protein in sporadic colorectal adenomas and its associations with clinical phenotype and histology.
World J Gastroenterol. 2006 Jun 28;12(24):3901-5.

Kanellos I, Zacharakis E, Kanellos D, Pramateftakis MG, Tsahalis T, Altsitsiadis E, Betsis D. Prognostic significance of CEA levels and detection of CEA mRNA in draining venous blood in patients with colorectal cancer. J Surg Oncol. 2006 Jul 1;94(1):3-8.

Zhang W, Gordon M, Press OA, Rhodes K, Vallbohmer D, Yang DY, Park D, Fazzone W, Schultheis A, Sherrod AE, Iqbal S, Groshen S, Lenz HJ. Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab.
Pharmacogenet Genomics. 2006 Jul;16(7):475-83.

Trusky CL, Sepulveda AR, Hunt JL. Assessment of microsatellite instability in very small microdissected samples and in tumor samples that are contaminated with normal DNA.
Diagn Mol Pathol. 2006 Jun;15(2):63-9.

Gunter MJ, Canzian F, Landi S, Chanock SJ, Sinha R, Rothman N. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1126-31.

Zou H, Harrington JJ, Klatt KK, Ahlquist DA.A sensitive method to quantify human long DNA in stool: relevance to colorectal cancer screening. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1115-9.

Peterlongo P, Mitra N, de Abajo AS, de la Hoya M, Bassi C, Bertario L, Radice P, Glogowski E, Nafa K, Caldes T, Offit K, Ellis NA. Increased frequency of disease-causing MYH mutations in colon cancer families.
Carcinogenesis. 2006 Jun 14;

Bianchini M, Levy E, Zucchini C, Pinski V, Macagno C, De Sanctis P, Valvassori L, Carinci P, Mordoh J. Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa. Int J Oncol. 2006 Jul;29(1):83-94.

Des Guetz G, Uzzan B, Nicolas P, Cucherat M, Morere JF, Benamouzig R, Breau JL, Perret GY. Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature. Br J Cancer. 2006 Jun 19;94(12):1823-32.

Shioiri M, Shida T, Koda K, Oda K, Seike K, Nishimura M, Takano S, Miyazaki M. Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients.
Br J Cancer. 2006 Jun 19;94(12):1816-22.

Ohlsson L, Hammarstrom ML, Israelsson A, Naslund L, Oberg A, Lindmark G, Hammarstrom S. Biomarker selection for detection of occult tumour cells in lymph nodes of colorectal cancer patients using real-time quantitative RT-PCR.
Br J Cancer. 2006 Jul 17;95(2):218-25

Wang JY, Wu CH, Lu CY, Hsieh JS, Wu DC, Huang SY, Lin SR. Molecular detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer using RT-PCR: significance of the prediction of postoperative metastasis.
World J Surg. 2006 Jun;30(6):1007-13.  

Madoz-Gurpide J, Lopez-Serra P, Martinez-Torrecuadrada JL, Sanchez L, Lombardia L, Casal JI. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.
Mol Cell Proteomics. 2006 Aug;5(8):1471-83.

Huang CC, Cheng YW, Chen MC, Lin YS, Chou MC, Lee H. Different p53 mutation patterns in colorectal tumors from smokers and nonsmokers. Environ Mol Mutagen. 2006 Aug;47(7):527-32.

Xu D, Li XF, Zheng S, Jiang WZ. Quantitative real-time RT-PCR detection for CEA, CK20 and CK19 mRNA in peripheral blood of colorectal cancer patients. J Zhejiang Univ Sci B. 2006 Jun;7(6):445-51.

Bi X, Lin Q, Foo TW, Joshi S, You T, Shen HM, Ong CN, Cheah PY, Eu KW, Hew CL. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.
Mol Cell Proteomics. 2006 Jun;5(6):1119-30.

Francoual M, Etienne-Grimaldi MC, Formento JL, Benchimol D, Bourgeon A, Chazal M, Letoublon C, Andre T, Gilly N, Delpero JR, Lasser P, Spano JP, Milano G. EGFR in colorectal cancer: more than a simple receptor. Ann Oncol. 2006 Jun;17(6):962-7.

Funaioli C, Pinto C, Mutri V, Fabio FD, Ceccarelli C, Martoni AA. Does Biomolecular Characterization of Stage II/III Colorectal Cancer Have Any Prognostic Value? Clin Colorectal Cancer. 2006 May;6(1):38-45.

Gibson TB, Ranganathan A, Grothey A. Randomized Phase III Trial Results of Panitumumab, a Fully Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody, in Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2006 May;6(1):29-31.

De Bruin JH, Ligtenberg MJ, Nagengast FM, Adang EM, Van Krieken JH, Hoogerbrugge N. Optimizing the detection of hereditary non-polyposis colorectal cancer: An update.
Scand J Gastroenterol Suppl. 2006 May;(243):146-52.

Mamot C, Ritschard R, Kung W, Park JW, Herrmann R, Rochlitz CF. EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells.
J Drug Target. 2006 May;14(4):215-23.

Madoz-Gurpide J, Lopez-Serra P, Martinez-Torrecuadrada JL, Sanchez L, Lombardia L, Casal JI. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.
Mol Cell Proteomics. 2006 May 29;

Lamberti C, Lundin S, Bogdanow M, Pagenstecher C, Friedrichs N, Buttner R, Sauerbruch T. Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer. Int J Colorectal Dis. 2006 May 25;

Lanza G, Gafa R, Santini A, Maestri I, Guerzoni L, Cavazzini L. Immunohistochemical test for MLH1 and MSH2 expression predicts clinical outcome in stage II and III colorectal cancer patients.
J Clin Oncol. 2006 May 20;24(15):2359-67.  

Wang JY, Wu CH, Lu CY, Hsieh JS, Wu DC, Huang SY, Lin SR. Molecular Detection of Circulating Tumor Cells in the Peripheral Blood of Patients with Colorectal Cancer Using RT-PCR: Significance of the Prediction of Postoperative Metastasis.
World J Surg. 2006 May 4;

Tsai WS, Changchien CR, Yeh CY, Chen JS, Tang R, Chiang JM, Hsieh PS, Fan CW, Wang JY. Preoperative Plasma Vascular Endothelial Growth Factor But Not Nitrite Is a Useful Complementary Tumor Marker in Patients With Colorectal Cancer.
Dis Colon Rectum. 2006 Apr 28;

Sugai T, Habano W, Jiao YF, Tsukahara M, Takeda Y, Otsuka K, Nakamura S. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn. 2006 May;8(2):193-201.

Douard R, Wind P, Sales JP, Landi B, Berger A, Benichou J, Gayral F, Loric S, Cugnenc PH. Long-term prognostic value of detection of circulating colorectal cancer cells using CGM2 reverse transcriptase-polymerase chain reaction assay.
Surgery. 2006 Apr;139(4):556-62.

Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Cote JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
Cancer Res. 2006 Apr 15;66(8):3992-5.

Watanabe T, Komuro Y, Kiyomatsu T, Kanazawa T, Kazama Y, Tanaka J, Tanaka T, Yamamoto Y, Shirane M, Muto T, Nagawa H. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profiles. Cancer Res. 2006 Apr 1;66(7):3370-4.

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Vincenzi B, Santini D, Russo A, Silletta M, Gavasci M, Battistoni F, Di Cuonzo G, Rocci L, Gebbia N, Tonini G. Angiogenesis modifications related with cetuximab plus irinotecan as anticancer treatment in advanced colorectal cancer patients.
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Fraser CG, Matthew CM, Mowat NA, Wilson JA, Carey FA, Steele RJ. Immunochemical testing of individuals positive for guaiac faecal occult blood test in a screening programme for colorectal cancer: an observational study. Lancet Oncol. 2006 Feb;7(2):127-31. 

Giribaldi G, Procida S, Ulliers D, Mannu F, Volpatto R, Mandili G, Fanchini L, Bertetto O, Fronda G, Simula L, Rimini E, Cherchi G, Bonello L, Maule MM, Turrini F. Specific detection of cytokeratin 20-positive cells in blood of colorectal and breast cancer patients by a high sensitivity real-time reverse transcriptase-polymerase chain reaction method. J Mol Diagn. 2006 Feb;8(1):105-12.  

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Famulski W, Sulkowska M, Wincewicz A, Kedra B, Pawlak K, Zalewski B, Sulkowski S, Koda M, Baltaziak M.  P53 correlates positively with VEGF in preoperative sera of colorectal cancer patients. Neoplasma. 2006;53(1):43-8.  

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Gordon MA, Gil J, Lu B, Zhang W, Yang D, Yun J, Schneider S, Groshen S, Iqbal S, Press OA, Rhodes K, Lenz HJ. Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation. Pharmacogenomics. 2006 Jan;7(1):67-88. 

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Sadahiro S, Suzuki T, Ishikawa K, Saguchi T, Maeda Y, Yasuda S, Makuuchi H, Yurimoto S, Murayama C. Detection of carcinoembryonic antigen messenger RNA-expressing cells in portal and peripheral blood during surgery does not influence relapse in colorectal cancer. Ann Surg Oncol. 2005 Dec;12(12):988-94. 

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Van Schaeybroeck S, Karaiskou-McCaul A, Kelly D, Longley D, Galligan L, Van Cutsem E, Johnston P. Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. 

Losi L, Di Gregorio C, Pedroni M, Ponti G, Roncucci L, Scarselli A, Genuardi M, Baglioni S, Marino M, Rossi G, Benatti P, Maffei S, Menigatti M, Roncari B, Ponz de Leon M. Zolecular genetic alterations and clinical features in early-onset colorectal carcinomas and their role for the recognition of hereditary cancer syndromes. Am J Gastroenterol. 2005 Oct;100(10):2280-7.  

Russo A, Bazan V, Iacopetta B, Kerr D, Soussi T, Gebbia N; TP53-CRC Collaborative Study Group. The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol. 2005 Oct 20;23(30):7518-28. 

Arango D, Laiho P, Kokko A, Alhopuro P, Sammalkorpi H, Salovaara R, Nicorici D, Hautaniemi S, Alazzouzi H, Mecklin JP, Jarvinen H, Hemminki A, Astola J, Schwartz S Jr, Aaltonen LA. Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer. Gastroenterology. 2005 Sep;129(3):874-84.  

Olson J, Whitney DH, Durkee K, Shuber AP. DNA stabilization is critical for maximizing performance of fecal DNA-based colorectal cancer tests. Diagn Mol Pathol. 2005 Sep;14(3):183-91.  

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Duff SE, Saunders M, McCredie V, Kumar S, O'Dwyer ST, Jayson GC. Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer. Clin Oncol (R Coll Radiol). 2005 Aug;17(5):367-71. 

Stormorken AT, Bowitz-Lothe IM, Noren T, Kure E, Aase S, Wijnen J, Apold J, Heimdal K, Moller P. Immunohistochemistry identifies carriers of mismatch repair gene defects causing hereditary nonpolyposis colorectal cancer. J Clin Oncol. 2005 Jul 20;23(21):4705-12. 

Watson NF, Madjd Z, Scrimegour D, Spendlove I, Ellis IO, Scholefield JH, Durrant LG. Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients.
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Beets-Tan RG, Lettinga T, Beets GL. Pre-operative imaging of rectal cancer and its impact on surgical performance and treatment outcome. Eur J Surg Oncol. 2005 Aug;31(6):681-8.  

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Engel C, Forberg J, Holinski-Feder E, Pagenstecher C, Plaschke J, Kloor M, Poremba C, Pox CP, Ruschoff J, Keller G, Dietmaier W, Rummele P, Friedrichs N, Mangold E, Buettner R, Schackert HK, Kienle P, Stemmler S, Moeslein G, Loeffler M. Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. Int J Cancer. 2005 Jul 7; 

Komuro Y, Watanabe T, Tsurita G, Muto T, Nagawa H. Expression pattern of telomerase reverse transcriptase in rectal carcinoma predicts tumor radiosensitivity, local recurrence and disease-free survival. Hepatogastroenterology. 2005 Jul-Aug;52(64):985-9.  

Fux R, Schwab M, Thon KP, Gleiter CH, Fritz P. Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. Clin Cancer Res. 2005 Jul 1;11(13):4754-60.  

Schoen RE, Weissfeld JL, Kuller LH, Thaete FL, Evans RW, Hayes RB, Rosen CJ. Insulin-like growth factor-I and insulin are associated with the presence and advancement of adenomatous polyps. Gastroenterology. 2005 Aug;129(2):464-75.  

Endo K, Kohnoe S, Tsujita E, Watanabe A, Nakashima H, Baba H, Maehara Y. Galectin-3 expression is a potent prognostic marker in colorectal cancer. Anticancer Res. 2005 Jul-Aug;25(4):3117-21.  

Krajewska M, Kim H, Kim C, Kang H, Welsh K, Matsuzawa S, Tsukamoto M, Thomas RG, Assa-Munt N, Piao Z, Suzuki K, Perucho M, Krajewski S, Reed JC. Analysis of apoptosis protein expression in early-stage colorectal cancer suggests opportunities for new prognostic biomarkers. Clin Cancer Res. 2005 Aug 1;11(15):5451-61.  

Sagynaliev E, Steinert R, Nestler G, Lippert H, Knoch M, Reymond MA. Web-based data warehouse on gene expression in human colorectal cancer. Proteomics. 2005 Aug;5(12):3066-78.  

Italiano A, Saint-Paul MC, Caroli-Bosc FX, Francois E, Bourgeon A, Benchimol D, Gugenheim J, Michiels JF. Epidermal growth factor receptor (EGFR) status in primary colorectal tumors correlates with EGFR expression in related metastatic sites: biological and clinical implications. Ann Oncol. 2005 Sep;16(9):1503-1507.  

Davies M, Gupta S, Goldspink G, Winslet M. The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence. Int J Colorectal Dis. 2005 Jun 16 

Smirnov DA, Zweitzig DR, Foulk BW, Miller MC, Doyle GV, Pienta KJ, Meropol NJ, Weiner LM, Cohen SJ, Moreno JG, Connelly MC, Terstappen LW, O'Hara SM. Global gene expression profiling of circulating tumor cells. Cancer Res. 2005 Jun 15;65(12):4993-7.  

Kruhoffer M, Jensen JL, Laiho P, Dyrskjot L, Salovaara R, Arango D, Birkenkamp-Demtroder K, Sorensen FB, Christensen LL, Buhl L, Mecklin JP, Jarvinen H, Thykjaer T, Wikman FP, Bech-Knudsen F, Juhola M, Nupponen NN, Laurberg S, Andersen CL, Aaltonen LA, Orntoft TF. Gene expression signatures for colorectal cancer microsatellite status and HNPCC. Br J Cancer. 2005 Jun 20;92(12):2240-8. 

Croner RS, Peters A, Brueckl WM, Matzel KE, Klein-Hitpass L, Brabletz T, Papadopoulos T, Hohenberger W, Reingruber B, Lausen B. Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma. Cancer. 2005 Jul 15;104(2):395-404.  

Kwong KY, Bloom GC, Yang I, Boulware D, Coppola D, Haseman J, Chen E, McGrath A, Makusky AJ, Taylor J, Steiner S, Zhou J, Yeatman TJ, Quackenbush J. Synchronous global assessment of gene and protein expression in colorectal cancer progression.
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de Jong KP, Gouw AS, Peeters PM, Bulthuis M, Menkema L, Porte RJ, Slooff MJ, van Goor H, van den Berg A. P53 mutation analysis of colorectal liver metastases: relation to actual survival, angiogenic status, and p53 overexpression. Clin Cancer Res. 2005 Jun 1;11(11):4067-73. 

Croner RS, Foertsch T, Brueckl WM, Guenther K, Siebenhaar R, Stremmel C, Matzel KE, Papadopoulos T, Kirchner T, Behrens J, Klein-Hitpass L, Stuerzl M, Hohenberger W, Reingruber B.       Common denominator genes that distinguish colorectal carcinoma from normal mucosa. Int J Colorectal Dis. 2005 Jul;20(4):353-62. Epub 2004 Dec 22.

Wang JY, Yeh CS, Tzou WS, Hsieh JS, Chen FM, Lu CY, Yu FJ, Cheng TL, Huang TJ, Lin SR. Analysis of progressively overexpressed genes in tumorigenesis of colorectal cancers using cDNA microarray. Oncol Rep. 2005 Jul;14(1):65-72.  

Ponnelle T, Chapusot C, Martin L, Bouvier AM, Plenchette S, Faivre J, Solary E, Piard F. Cellular localisation of Survivin: impact on the prognosis in colorectal cancer. J Cancer Res Clin Oncol. 2005 Aug;131(8):504-510. 

Hsieh JS, Lin SR, Chang MY, Chen FM, Lu CY, Huang TJ, Huang YS, Huang CJ, Wang JY. APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
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Feng B, Zheng MH, Zheng YF, Lu AG, Li JW, Wang ML, Ma JJ, Xu GW, Yu BM.  [Application of urinary nucleosides in the diagnosis and surgical monitoring of colorectal cancer.] Zhonghua Wai Ke Za Zhi. 2005 May 7;43(9):564-8.  

Bazan V, Agnese V, Corsale S, Calo V, Valerio MR, Latteri MA, Vieni S, Grassi N, Cicero G, Dardanoni G, Tomasino RM, Colucci G, Gebbia N, Russo A. Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. Ann Oncol. 2005 May;16 Suppl 4:iv50-iv55.  

Russo A, Bazan V, Agnese V, Rodolico V, Gebbia N. Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies. Ann Oncol. 2005 May;16 Suppl 4:iv44-iv49.   

Aguiar S Jr, Lopes A, Soares FA, Rossi BM, Ferreira FO, Nakagawa WT, Carvalho AL, David Filho WJ Prognostic and predictive value of the thymidylate synthase expression in patients with non-metastatic colorectal cancer.
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Vallbohmer D, Zhang W, Gordon M, Yang DY, Yun J, Press OA, Rhodes KE, Sherrod AE, Iqbal S, Danenberg KD, Groshen S, Lenz HJ. Molecular determinants of cetuximab efficacy. J Clin Oncol. 2005 May 20;23(15):3536-44.  

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Keese M, Magdeburg RJ, Herzog T, Hasenberg T, Offterdinger M, Pepperkok R, Sturm JW, Bastiaens PI. Imaging epidermal growth factor receptor phosphorylation in human colorectal cancer cells and human tissues. J Biol Chem. 2005 May 20; 

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Chang HJ, Jung KH, Kim DY, Jeong SY, Choi HS, Kim YH, Sohn DK, Yoo BC, Lim SB, Kim DH, Ahn JB, Kim IJ, Kim JM, Yoon WH, Park JG. Bax, a predictive marker for therapeutic response to preoperative chemoradiotherapy in patients with rectal carcinoma. Hum Pathol. 2005 Apr;36(4):364-71.  

Banerjea A, Bustin SA, Dorudi S. The immunogenicity of colorectal cancers with high-degree microsatellite instability. World J Surg Oncol. 2005 May 12;3(1):26

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Salto-Tellez M, Tan SY, Chiu LL, Koay ES. Dinucleotide microsatellite repeats are essential for the diagnosis of microsatellite instability in colorectal cancer in Asian patients. World J Gastroenterol. 2005 May 14;11(18):2781-3.  

Friederichs J, Rosenberg R, Mages J, Janssen KP, Maeckl C, Nekarda H, Holzmann B, Siewert JR. Gene expression profiles of different clinical stages of colorectal carcinoma: toward a molecular genetic understanding of tumor progression. Int J Colorectal Dis. 2005 May 10;  

Uchida K, Schneider S, Yochim JM, Kuramochi H, Hayashi K, Takasaki K, Yang D, Danenberg KD, Danenberg PV. Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. Clin Cancer Res. 2005 May 1;11(9):3363-8.  

Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005 May;6(5):279-86. 

Buckowitz A, Knaebel HP, Benner A, Blaker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer. 2005 May 9;92(9):1746-53.  

Conlin A, Smith G, Carey FA, Wolf CR, Steele RJ. The prognostic significance of K-ras, p53 and APC mutations in colorectal carcinoma. Gut. 2005 Apr 20;  

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Velayos FS, Allen BA, Conrad PG, Gum J Jr, Kakar S, Chung DC, Truta B, Sleisenger MH, Kim YS, Terdiman JP.  Low rate of microsatellite instability in young patients with adenomas: reassessing the Bethesda guidelines. Am J Gastroenterol. 2005 May;100(5):1143-9. 

Gao JF, Arbman G, Wadhra TI, Zhang H, Sun XF. Relationships of tumor inflammatory infiltration and necrosis with microsatellite instability in colorectal cancers. World J Gastroenterol. 2005 Apr 14;11(14):2179-83.  

Ghadimi BM, Grade M, Difilippantonio MJ, Varma S, Simon R, Montagna C, Fuzesi L, Langer C, Becker H, Liersch T, Ried T. Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. J Clin Oncol. 2005 Mar 20;23(9):1826-38.  

Zhang YZ, Sheng JQ, Li SR, Zhang H. Clinical phenotype and prevalence of hereditary nonpolyposis colorectal cancer syndrome in Chinese population. World J Gastroenterol. 2005 Mar 14;11(10):1481-8. 

Lebe B, Sarioglu S, Sokmen S, Ellidokuz H, Fuzun M, Kupelioglu A. The clinical significance of p53, p21, and p27 expressions in rectal carcinoma. Appl Immunohistochem Mol Morphol. 2005 Mar;13(1):38-44 

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Langenskiold M, Holmdahl L, Falk P, Ivarsson ML. Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer. Int J Colorectal Dis. 2005 May;20(3):245-52.  

Saito N, Kameoka S. Serum laminin is an independent prognostic factor in colorectal cancer. Int J Colorectal Dis. 2005 May;20(3):238-44

Conzelmann M, Linnemann U, Berger MR. Molecular detection of clinical colorectal cancer metastasis: how should multiple markers be put to use? Int J Colorectal Dis. 2005 Mar;20(2):137-46.  

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Xiong B, Sun TJ, Hu WD, Cheng FL, Mao M, Zhou YF. Expression of cyclooxygenase-2 in colorectal cancer and its clinical significance. World J Gastroenterol. 2005 Feb 28;11(8):1105-8.  

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Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, Hamilton A, Pan D, Schrag D, Schwartz L, Klimstra DS, Fridman D, Kelsen DP, Saltz LB. Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry. J Clin Oncol. 2005 Jan 27;  

Peeters CF, de Geus LF, Westphal JR, de Waal RM, Ruiter DJ, Wobbes T, Oyen WJ, Ruers TJ. Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases. Surgery. 2005 Feb;137(2):246-9.  

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Chapusot C, Martin L, Puig PL, Ponnelle T, Cheynel N, Bouvier AM, Rageot D, Roignot P, Rat P, Faivre J, Piard F.  What is the best way to assess microsatellite instability status in colorectal cancer? Study on a population base of 462 colorectal cancers. Am J Surg Pathol. 2004 Dec;28(12):1553-9.  

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Chang SC, Lin JK, Lin TC, Liang WY. Genetic alteration of p53, but not overexpression of intratumoral p53 protein, or serum p53 antibody is a prognostic factor in sporadic colorectal adenocarcinoma.
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Calistri D, Rengucci C, Lattuneddu A, Francioni G, Polifemo AM, Nanni O, Saragoni L, Monti F, Ravaioli A, Zoli W, Amadori D. Detection of colorectal cancer by a quantitative fluorescence determination of DNA amplification in stool. Neoplasia. 2004 Sep-Oct;6(5):536-40

Tada T, Watanabe T, Kanazawa T, Kazama S, Koketsu S, Nagawa H. Genetic characterization of colorectal cancers in young patients based on chromosomal loss and microsatellite instability. Scand J Gastroenterol. 2004 Nov;39(11):1134-40.  

Bertario L, Russo A, Sala P, Varesco L, Crucianelli R, Frattini M, Pierotti MA, Radice P; Hereditary Colorectal Tumors Registry. APC genotype is not a prognostic factor in familial adenomatous polyposis patients with colorectal cancer. Dis Colon Rectum. 2004 Oct;47(10):1662-9. 

Dundas SR, Lawrie LC, Rooney PH, Murray GI. Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival. J Pathol. 2004 Nov 8;205(1):74-81  

Haddad R, Ogilvie RT, Croitoru M, Muniz V, Gryfe R, Pollet A, Shanmugathasan P, Fitzgerald T, Law CH, Hanna SS, Jothy S, Redston M, Gallinger S, Smith AJ. Microsatellite instability as a prognostic factor in resected colorectal cancer liver metastases.
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Charara M, Edmonston TB, Burkholder S, Walters R, Anne P, Mitchell E, Fry R, Boman B, Rose D, Fishel R, Curran W, Palazzo J. Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy. Anticancer Res. 2004 Sep-Oct;24(5B):3161-7.  

Whitney D, Skoletsky J, Moore K, Boynton K, Kann L, Brand R, Syngal S, Lawson M, Shuber A. Enhanced retrieval of DNA from human fecal samples results in improved performance of colorectal cancer screening test. J Mol Diagn. 2004 Nov;6(4):386-95.  

Muller A, Giuffre G, Edmonston TB, Mathiak M, Roggendorf B, Heinmoller E, Brodegger T, Tuccari G, Mangold E, Buettner R, Ruschoff J; German HNPCC Consortium German Cancer Aid (Deutsche Krebshilfe). Challenges and pitfalls in HNPCC screening by microsatellite analysis and immunohistochemistry. J Mol Diagn. 2004 Nov;6(4):308-15.  

Kakar S, Smyrk TC. Signet ring cell carcinoma of the colorectum: correlations between microsatellite instability, clinicopathologic features and survival. Mod Pathol. 2004 Oct 15;  

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Bilenker JH, Haller DG. Future directions with angiogenesis inhibitors in colorectal cancer. Clin Colorectal Cancer. 2004 Oct;4 Suppl 2:S86-93. 

Konner J, Dupont J. Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity. Clin Colorectal Cancer. 2004 Oct;4 Suppl 2:S81-5.   

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Yu JK, Yang MQ, Jiang TJ, Zheng S. The optimal combination of serum tumor markers with bioinformatics in diagnosis of colorectal carcinoma. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Sep;33(5):407-10. Chinese.

Bahnassy AA, Zekri AR, El-Houssini S, El-Shehaby AM, Mahmoud MR, Abdallah S, El-Serafi M Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterol. 2004 Sep 23;4(1):22.  

Bocci G, Man S, Green SK, Francia G, Ebos JM, du Manoir JM, Weinerman A, Emmenegger U, Ma L, Thorpe P, Davidoff A, Huber J, Hicklin DJ, Kerbel RS. Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res. 2004 Sep 15;64(18):6616-25.  

Yuan HY, Cheng FL, Wei ZZ, Yang GL, Chen JK.  [Clinical significance of detecting lymph node micrometastasis of colorectal cancer by reverse transcriptase-polymerase chain reaction (RT-PCR)] Ai Zheng. 2004 Sep;23(9):1069-73. Chinese.  

Konner J, Dupont J. Use of soluble recombinant decoy receptor vascular endothelial growth factor trap (VEGF Trap) to inhibit vascular endothelial growth factor activity. Clin Colorectal Cancer. 2004 Oct;4 Suppl 2:S81-5.  

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Hurwitz H. Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapy in advanced colorectal cancer.Clin Colorectal Cancer. 2004 Oct;4 Suppl 2:S62-8.

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Bahnassy AA, Zekri AR, El-Houssini S, El-Shehaby AM, Mahmoud MR, Abdallah S, El-Serafi M. Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroenterol. 2004 Sep 23;4(1):22.  

Bocci G, Man S, Green SK, Francia G, Ebos JM, du Manoir JM, Weinerman A, Emmenegger U, Ma L, Thorpe P, Davidoff A, Huber J, Hicklin DJ, Kerbel RS. Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res. 2004 Sep 15;64(18):6616-25.  

Kim BS, Kim I, Lee S, Kim S, Rha SY, Chung HC. Statistical methods of translating microarray data into clinically relevant diagnostic information in colorectal cancer. Bioinformatics. 2004 Sep 16;  

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Yuan HY, Cheng FL, Wei ZZ, Yang GL, Chen JK.  [Clinical significance of detecting lymph node micrometastasis of colorectal cancer by reverse transcriptase-polymerase chain reaction (RT-PCR)] Ai Zheng. 2004 Sep;23(9):1069-73. Chinese. 

Jover R, Paya A, Alenda C, Poveda MJ, Peiro G, Aranda FI, Perez-Mateo M. Defective mismatch-repair colorectal cancer: clinicopathologic characteristics and usefulness of immunohistochemical analysis for diagnosis. Am J Clin Pathol. 2004 Sep;122(3):389-94.  

Knutsen A, Adell G, Sun XF. Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):149-55.  

Chen WC, Liu Q, Fu JX, Kang SY. Expression of survivin and its significance in colorectal cancer. World J Gastroenterol. 2004 Oct 1;10(19):2886-9. 

Church RD, Yu J, Fleshman JW, Shannon WD, Govindan R, McLeod HL. RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. Br J Cancer. 2004 Sep 13;91(6):1015-8.  

Jaszewski R, Levi E, Sochacki P, Frank J, Kucuk O, Axelrod BN, Majumdar AP. Expression of epidermal growth factor-receptor related protein (ERRP) in human colorectal carcinogenesis. Cancer Lett. 2004 Sep 30;213(2):249-55.  

Koehler A, Bataille F, Schmid C, Ruemmele P, Waldeck A, Blaszyk H, Hartmann A, Hofstaedter F, Dietmaier W. Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage. J Pathol. 2004 Sep;204(1):65-74. 

Fernebro E, Bendahl PO, Dictor M, Persson A, Ferno M, Nilbert M. Immunohistochemical patterns in rectal cancer: application of tissue microarray with prognostic correlations. Int J Cancer. 2004 Oct 10;111(6):921-8. 

Takayama O, Yamamoto H, Ikeda K, Ishida H, Kato T, Okuyama M, Kanou T, Fukunaga M, Tominaga S, Morita S, Fujie Y, Fukunaga H, Ikenaga M, Ikeda M, Ohue M, Sekimoto M, Kikkawa N, Monden M. Application of RT-PCR to clinical diagnosis of micrometastasis of colorectal cancer: A translational research study. Int J Oncol. 2004 Sep;25(3):597-604.  

Lim SB, Jeong SY, Lee MR, Ku JL, Shin YK, Kim WH, Park JG. Prognostic significance of microsatellite instability in sporadic colorectal cancer. Int J Colorectal Dis. 2004 Nov;19(6):533-7.  

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Chin KF, Greenman J, Reusch P, Gardiner E, Marme D, Monson J. Changes in serum soluble VEGFR-1 and Tie-2 receptors in colorectal cancer patients following surgical resections. Anticancer Res. 2004 Jul-Aug;24(4):2353-7.  

Church RD, Yu J, Fleshman JW, Shannon WD, Govindan R, McLeod HL. RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer. Br J Cancer. 2004 Aug 24  

Takeuchi T, Hisanaga M, Nagao M, Ikeda N, Fujii H, Koyama F, Mukogawa T, Matsumoto H, Kondo S, Takahashi C, Noda M, Nakajima Y. The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clin Cancer Res. 2004 Aug 15;10(16):5572-9. 

Broll R, Busch P, Duchrow M, Oevermann E, Schwandner O, Farke S, Bruch HP, Windhovel U. Influence of thymidylate synthase and p53 protein expression on clinical outcome in patients with colorectal cancer. Int J Colorectal Dis. 2004 Aug 10 

Kanaoka S, Yoshida K, Miura N, Sugimura H, Kajimura M. Potential usefulness of detecting cyclooxygenase 2 messenger RNA in feces for colorectal cancer screening. Gastroenterology. 2004 Aug;127(2):422-7.  

Banerjea A, Ahmed S, Hands RE, Huang F, Han X, Shaw PM, Feakins R, Bustin SA, Dorudi S. Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity.
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Mak T, Lalloo F, Evans DG, Hill J. Molecular stool screening for colorectal cancer. Br J Surg. 2004 Jul;91(7):790-800. Review. 

Lage PA, Albuquerque C, Sousa RG, Cravo ML, Salazar M, Francisco I, Maia L, Claro I, Suspiro A, Rodrigues P, Raposo H, Fidalgo PA, Nobre-Leitao C. Association of colonic and endometrial carcinomas in Portuguese families with hereditary nonpolyposis colorectal carcinoma significantly increases the probability of detecting a pathogenic mutation in mismatch repair genes, primarily the MSH2 gene. Cancer. 2004 Jul 1;101(1):172-7 

Kunstmann E, Vieland J, Brasch FE, Hahn SA, Epplen JT, Schulmann K, Schmiegel W. HNPCC: six new pathogenic mutations. BMC Med Genet. 2004 Jun 24;5(1):16.  

Kim H, Nam SW, Rhee H, Shan Li L, Ju Kang H, Hye Koh K, Kyu Kim N, Song J, Tak-Bun Liu E, Kim H. Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas.
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Croner RS, Guenther K, Foertsch T, Siebenhaar R, Brueckl WM, Stremmel C, Hlubek F, Hohenberger W, Reingruber B. Tissue preparation for gene expression profiling of colorectal carcinoma: three alternatives to laser microdissection with preamplification.  Lab Clin Med. 2004 Jun;143(6):344-51.  

Tagore KS, Levin TR, Lawson MJ. The evolution to stool DNA testing for colorectal cancer. Aliment Pharmacol Ther. 2004 Jun 15;19(12):1225-33. 

Wang JY, Hsieh JS, Chang MY, Huang TJ, Chen FM, Cheng TL, Alexandersen K, Huang YS, Tzou WS, Lin SR. Molecular Detection of APC, K- ras, and p53 Mutations in the Serum of Colorectal Cancer Patients as Circulating Biomarkers. World J Surg. 2004 Jun 8  

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Galizia G, Lieto E, Ferraraccio F, Orditura M, De Vita F, Castellano P, Imperatore V, Romano C, Ciardiello F, Agostini B, Pignatelli C. Determination of molecular marker expression can predict clinical outcome in colon carcinomas. Clin Cancer Res. 2004 May 15;10(10):3490-9.

Gal R, Sadikov E, Sulkes J, Klein B, Koren R. Deleted in Colorectal Cancer Protein Expression as a Possible Predictor of Response to Adjuvant Chemotherapy in Colorectal Cancer Patients. Dis Colon Rectum. 2004 May 20 

Gertler R, Rosenberg R, Stricker D, Friederichs J, Hoos A, Werner M, Ulm K, Holzmann B, Nekarda H, Siewert JR.Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol. 2004 May 15;22(10):1807-14.

Patten LC, Berger DH, Rodriguez-Bigas M, Mansfield P, Delpassand E, Cleary KR, Fagan SP, Curley SA, Hunt KK, Feig BW. A prospective evaluation of radiocolloid and immunohistochemical staining in colon carcinoma lymphatic mapping. Cancer. 2004 May 15;100(10):2104-9.

Li SY, Yu B, An P, Wei JC, Zuo FY, Cai HY. Influence of FasL gene expression on hepatic metastasis of colorectal carcinoma. Hepatobiliary Pancreat Dis Int. 2004 May;3(2):226-9.  

Song K, Fendrick AM, Ladabaum U. Fecal DNA testing compared with conventional colorectal cancer screening methods: a decision analysis. Gastroenterology. 2004 May;126(5):1270-9.  

Schiemann U, Muller-Koch Y, Gross M, Daum J, Lohse P, Baretton G, Muders M, Mussack T, Kopp R, Holinski-Feder E.Extended Microsatellite Analysis in Microsatellite Stable, MSH2 and MLH1 Mutation-Negative HNPCC Patients: Genetic Reclassification and Correlation with Clinical Features.
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Brink M, Weijenberg MP, De Goeij AF, Schouten LJ, Koedijk FD, Roemen GM, Lentjes MH, De Bruine AP, Goldbohm RA, Van Den Brandt PA.Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis. 2004 Apr 29  

Muller HM, Oberwalder M, Fiegl H, Morandell M, Goebel G, Zitt M, Muhlthaler M, Ofner D, Margreiter R, Widschwendter M. Methylation changes in faecal DNA: a marker for colorectal cancer screening?
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Cruz-Correa M, Cui H, Giardiello FM, Powe NR, Hylind L, Robinson A, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Feinberg AP. Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition. Gastroenterology. 2004 Apr;126(4):964-70.

Wang Y, Jatkoe T, Zhang Y, Mutch MG, Talantov D, Jiang J, McLeod HL, Atkins D. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol. 2004 May 1;22(9):1564-71.  

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Phillips SM, Banerjea A, Feakins R, Li SR, Bustin SA, Dorudi S. Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic. Br J Surg. 2004 Apr;91(4):469-75.  

Tsuji T, Sawai T, Yamashita H, Takeshita H, Nakagoe T, Shindou H, Fukuoka H, Yoshinaga M, Hidaka S, Yasutake T, Nagayasu T, Tagawa Y. Platelet-derived endothelial cell growth factor expression is an independent prognostic factor in colorectal cancer patients after curative surgery. Eur J Surg Oncol. 2004 Apr;30(3):296-302.  

Schmitz V, Wang L, Barajas M, Gomar C, Prieto J, Qian C. Treatment of colorectal and hepatocellular carcinomas by adenoviral mediated gene transfer of endostatin and angiostatin-like molecule in mice.
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Liang JT, Huang KC, Jeng YM, Lee PH, Lai HS, Hsu HC. Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. Br J Surg. 2004 Mar;91(3):355-61.  

Menon AG, Janssen-van Rhijn CM, Morreau H, Putter H, Tollenaar RA, van de Velde CJ, Fleuren GJ, Kuppen PJ. Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis. Lab Invest. 2004 Apr;84(4):493-501.  

Parc Y, Gueroult S, Mourra N, Serfaty L, Flejou JF, Tiret E, Parc R. Prognostic significance of microsatellite instability determined by immunohistochemical staining of MSH2 and MLH1 in sporadic T3N0M0 colon cancer. Gut. 2004 Mar;53(3):371-5.  

Lechpammer M, Lukac J, Lechpammer S, Kovacevic D, Loda M, Kusic Z. Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy.
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Lassmann S, Bauer M, Rosenberg R, Nekarda H, Soong R, Ruger R, Hofler H, Werner M. Identification of occult tumor cells in node negative lymph nodes of colorectal cancer patients by cytokeratin 20 gene and protein expression. Int J Colorectal Dis. 2004 Mar;19(2):87-94

Kirchhoff T, Satagopan JM, Kauff ND, Huang H, Kolachana P, Palmer C, Rapaport H, Nafa K, Ellis NA, Offit K.  Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer. J Natl Cancer Inst. 2004 Jan 7;96(1):68-70.

Marotta A, Parhar K, Owen D, Dedhar S, Salh B. Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. Br J Cancer. 2003 Jun 2;88(11):1755-62.

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Gupta RA, DuBois RN, Wallace MC. New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity. Best Pract Res Clin Gastroenterol. 2002 Dec;16(6):945-56.

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Yang IV, Chen E, Hasseman JP, Liang W, Frank BC, Wang S, Sharov V, Saeed AI, White J, Li J, Lee NH, Yeatman TJ, Quackenbush J.  Within the fold: assessing differential expression measures and reproducibility in microarray assays. Genome Biol. 2002 Oct 24;3(11):research0062.

Barratt PL, Seymour MT, Stenning SP, Georgiades I, Walker C, Birbeck K, Quirke P.  DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study. Lancet. 2002 Nov 2;360(9343):1381-91.

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Li JQ, Miki H, Wu F, Saoo K, Nishioka M, Ohmori M, Imaida K. Cyclin A correlates with carcinogenesis and metastasis, and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms.
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Sugiyama Y, Kato T, Nakazato H, Ito K, Mizuno I, Kanemitsu T, Matsumoto K, Yamaguchi A, Nakai K, Inada K, Tatematsu M. Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curatively resected colorectal cancer. Anticancer Drugs. 2002 Oct;13(9):931-8.

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Li SJ, Xiao B, Jiang B, Han Y. Expression of Fas genes transduced into colorectal cancer cells. Di Yi Jun Yi Da Xue Xue Bao. 2002 Aug;22(8):700-3.

Sun X, Wu BP, Xiao B, Zhang ZS, Lai ZS. Expression and identification of phage display library for Fab fragments of colorectal cancer-related antibodies. Di Yi Jun Yi Da Xue Xue Bao. 2002 Aug;22(8):678-83.

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Konturek PC, Bielanski W, Konturek SJ, Hartwich A, Pierzchalski P, Gonciarz M, Marlicz K, Starzynska T, Zuchowicz M, Darasz Z, Gotze JP, Rehfeld JF, Hahn EG. Progastrin and cyclooxygenase-2 in colorectal cancer. Dig Dis Sci. 2002 Sep;47(9):1984-91.

Kleeff J, Huang Y, Mok SC, Zimmermann A, Friess H, Buchler MW. Down-regulation of DOC-2 in colorectal cancer points to its role as a tumor suppressor in this malignancy. Dis Colon Rectum. 2002 Sep;45(9):1242-8.

Miyaki M, Iijima T, Yasuno M, Kita Y, Hishima T, Kuroki T, Mori T. High incidence of protein-truncating mutations of the p53 gene in liver metastases of colorectal carcinomas. Oncogene. 2002 Sep 26;21(43):6689-93.

Grabowski P, Schonfelder J, Ahnert-Hilger G, Foss HD, Heine B, Schindler I, Stein H, Berger G, Zeitz M, Scherubl H. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch. 2002 Sep;441(3):256-63.

Rodel F, Hoffmann J, Grabenbauer GG, Papadopoulos T, Weiss C, Gunther K, Schick C, Sauer R, Rodel C. High survivin expression is associated with reduced apoptosis in rectal cancer and may predict disease-free survival after preoperative radiochemotherapy and surgical resection. Strahlenther Onkol. 2002 Aug;178(8):426-35.

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Lovig T, Andersen SN, Thorstensen L, Diep CB, Meling GI, Lothe RA, Rognum TO. Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis.
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El-Bahrawy M, Talbot I, Poulsom R, Alison M. Variable nuclear localization of alpha-catenin in colorectal carcinoma. Lab Invest. 2002 Sep;82(9):1167-74.

Inoue H, Shiraki K, Yamanaka T, Ohmori S, Sakai T, Deguchi M, Okano H, Murata K, Sugimoto K, Nakano T. Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells. Lab Invest. 2002 Sep;82(9):1111-9.

Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Tsuno N, Kazama S, Kitayama J, Suzuki N, Nagawa H. The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer. 2002 Sep 15;95(6):1199-205

Geido E, Sciutto A, Rubagotti A, Oliani C, Monaco R, Risio M, Giaretti W. Combined DNA flow cytometry and sorting with k-ras2 mutation spectrum analysis and the prognosis of human sporadic colorectal cancer. Cytometry. 2002 Aug 15;50(4):216-24.

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Uthoff SM, Duchrow M, Schmidt MH, Broll R, Bruch HP, Strik MW, Galandiuk S. VEGF isoforms and mutations in human colorectal cancer. Int J Cancer. 2002 Sep 1;101(1):32-6.

Tang X, Sun YJ, Half E, Kuo MT, Sinicrope F. Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res. 2002 Sep 1;62(17):4903-8.

Ward R, Meldrum C, Williams R, Mokany E, Scott R, Turner J, Hawkins N, Burgess B, Groombridge C, Spigelman A. Impact of microsatellite testing and mismatch repair protein expression on the clinical interpretation of genetic testing in hereditary non-polyposis colorectal cancer. J Cancer Res Clin Oncol. 2002 Aug;128(8):403-11.

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Colombino M, Cossu A, Manca A, Dedola MF, Giordano M, Scintu F, Curci A, Avallone A, Comella G, Amoruso M, Margari A, Bonomo GM, Castriota M, Tanda F, Palmieri G. Prevalence and prognostic role of microsatellite instability in patients with rectal carcinoma. Ann Oncol. 2002 Sep;13(9):1447-53.

Bazan V, Migliavacca M, Zanna I, Tubiolo C, Grassi N, Latteri MA, La Farina M, Albanese I, Dardanoni G, Salerno S, Tomasino RM, Labianca R, Gebbia N, Russo A. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
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Watson SA, Morris TM, McWilliams DF, Harris J, Evans S, Smith A, Clarke PA. Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence. Br J Cancer. 2002 Aug 27;87(5):567-73.

Shimao Y, Nabeshima K, Inoue T, Koono M. Complex formation of IQGAP1 with E-cadherin/catenin during cohort migration of carcinoma cells. Its possible association with localized release from cell-cell adhesion.
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Chapusot C, Martin L, Bouvier AM, Bonithon-Kopp C, Ecarnot-Laubriet A, Rageot D, Ponnelle T, Laurent Puig P, Faivre J, Piard F. Microsatellite instability and intratumoural heterogeneity in 100 right-sided sporadic colon carcinomas. Br J Cancer. 2002 Aug 12;87(4):400-4.

Stathopoulou A, Vlachonikolis I, Mavroudis D, Perraki M, Kouroussis Ch, Apostolaki S, Malamos N, Kakolyris S, Kotsakis A, Xenidis N, Reppa D, Georgoulias V. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol. 2002 Aug 15;20(16):3404-12.

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Valentini AM, Renna L, Armentano R, Pirrelli M, Di Leo A, Gentile M, Caruso ML. Mismatch repair, p53 and beta-catenin proteins in colorectal cancer.
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Lavezzi AM, Ottaviani G, De Ruberto F, Fichera G, Matturri L. Prognostic significance of different biomarkers (DNA content, PCNA, karyotype) in colorectal adenomas. Anticancer Res. 2002 Jul-Aug;22(4):2077-81.

Xiong B, Yuan HY, Hu MB, Zhang F, Wei ZZ, Gong LL, Yang GL. Transforming growth factor-beta1 in invasion and metastasis in colorectal cancer. World J Gastroenterol. 2002 Aug;8(4):674-8.

Ye Z, Parry JM. Meta-analysis of 20 case-control studies on the N-acetyltransferase 2 acetylation status and colorectal cancer risk. Med Sci Monit. 2002 Aug;8(8):CR558-65.

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Ichikawa Y, Ishikawa T, Takahashi S, Hamaguchi Y, Morita T, Nishizuka I, Yamaguchi S, Endo I, Ike H, Togo S, Oki S, Shimada H, Kadota K, Nakamura S, Goto H, Nitanda H, Satomi S, Sakai T, Narita I, Gejyo F, Tomaru Y, Shimizu K, Hayashizaki Y, Okazaki Y. Identification of genes regulating colorectal carcinogenesis by using the algorithm for diagnosing malignant state method.
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Birkenkamp-Demtroder K, Christensen LL, Olesen SH, Frederiksen CM, Laiho P, Aaltonen LA, Laurberg S, Sorensen FB, Hagemann R, ORntoft TF. Gene expression in colorectal cancer. Cancer Res. 2002 Aug 1;62(15):4352-63.

Fournel M, Trachy-Bourget MC, Yan PT, Kalita A, Bonfils C, Beaulieu C, Frechette S, Leit S, Abou-Khalil E, Woo SH, Delorme D, MacLeod AR, Besterman JM, Li Z. Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors. Cancer Res. 2002 Aug 1;62(15):4325-30.

Ikawa K, Terashima Y, Sasaki K, Tashiro S. Genetic detection of liver micrometastases that are undetectable histologically. J Surg Res. 2002 Jul;106(1):124-30.

Cintin C, Johansen JS, Christensen IJ, Price PA, Sorensen S, Nielsen HJ. High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival. Cancer. 2002 Jul 15;95(2):267-74.

Nagatsuka I, Yamada N, Shimizu S, Ohira M, Nishino H, Seki S, Hirakawa K. Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. Int J Cancer. 2002 Aug 10;100(5):515-9.

Kern A, Taubert H, Scheele J, Rudroff C, Mothes H, Kappler M, Bartel F, Richter KK. Association of p53 mutations, microvessel density and neoangiogenesis in pairs of colorectal cancers and corresponding liver metastases. Int J Oncol. 2002 Aug;21(2):243-9.

Lanza G, Gafa R, Maestri I, Santini A, Matteuzzi M, Cavazzini L. Immunohistochemical pattern of MLH1/MSH2 expression is related to clinical and pathological features in colorectal adenocarcinomas with microsatellite instability. Mod Pathol. 2002 Jul;15(7):741-9.

Rebischung C, Gerard JP, Gayet J, Thomas G, Hamelin R, Laurent-Puig P. Prognostic value of P53 mutations in rectal carcinoma. Int J Cancer. 2002 Jul 10;100(2):131-5.

Choi SW, Lee KJ, Bae YA, Min KO, Kwon MS, Kim KM, Rhyu MG. Genetic classification of colorectal cancer based on chromosomal loss and microsatellite instability predicts survival. Clin Cancer Res. 2002 Jul;8(7):2311-22.

Bisgaard ML, Jager AC, Myrhoj T, Bernstein I, Nielsen FC. Hereditary non-polyposis colorectal cancer (HNPCC): phenotype-genotype correlation between patients with and without identified mutation. Hum Mutat. 2002 Jul;20(1):20-7.

Brabletz T, Jung A, Kirchner T. Beta-catenin and the morphogenesis of colorectal cancer. Virchows Arch. 2002 Jul;441(1):1-11. Review.

Millet A, Bettaieb A, Renaud F, Prevotat L, Hammann A, Solary E, Mignotte B, Jeannin JF. Influence of the nitric oxide donor glyceryl trinitrate on apoptotic pathways in human colon cancer cells. Gastroenterology. 2002 Jul;123(1):235-

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Koshiji M, Yonekura Y, Saito T, Sakaida N, Uemura Y, Yoshioka K. Genetic alterations in normal epithelium of colorectal cancer patients may be a useful indicator for subsequent metachronous tumor development. Ann Surg Oncol. 2002 Jul;9(6):580-6.

Rossi BM, Lopes A, Oliveira Ferreira F, Nakagawa WT, Napoli Ferreira CC, Casali Da Rocha JC, Simpson CC, Simpson AJ. hMLH1 and hMSH2 gene mutation in Brazilian families with suspected hereditary nonpolyposis colorectal cancer. Ann Surg Oncol. 2002 Jul;9(6):555-61.

Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg. 2002 Jul;89(7):845-60. Review.

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Koshiji M, Yonekura Y, Saito T, Sakaida N, Uemura Y, Yoshioka K. Genetic alterations in normal epithelium of colorectal cancer patients may be a useful indicator for subsequent metachronous tumor development. Ann Surg Oncol. 2002 Jul-Aug;9(6):580-6.

Rossi BM, Lopes A, Oliveira Ferreira F, Nakagawa WT, Napoli Ferreira CC, Casali Da Rocha JC, Simpson CC, Simpson AJ. hMLH1 and hMSH2 Gene Mutation in Brazilian Families With Suspected Hereditary Nonpolyposis Colorectal Cancer. Ann Surg Oncol. 2002 Jul-Aug;9(6):555-561.

Castagnetta L, Traina A, Campisi I, Calabro M, Maratta A, Saetta A, Agostara B, Mezzatesta N. Androgen receptor status in nontumoral and malignant human colorectal tissues. Ann N Y Acad Sci. 2002 Jun;963:322-5.

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Kanoh T, Monden T, Tamaki Y, Ohnishi T, Ikeda K, Izawa H, Sekimoto M, Tomita N, Monden M. Extraction and analysis of carcinoembryonic antigen in lymph nodes: a new approach to the diagnosis of lymph node metastasis of colorectal cancer. Dis Colon Rectum. 2002 Jun;45(6):757-63.

Toyooka S, Toyooka KO, Harada K, Miyajima K, Makarla P, Sathyanarayana UG, Yin J, Sato F, Shivapurkar N, Meltzer SJ, Gazdar AF. Aberrant methylation of the CDH13 (H-cadherin) promoter region in colorectal cancers and adenomas. Cancer Res. 2002 Jun 15;62(12):3382-6.

Bazan V, Migliavacca M, Tubiolo C, Macaluso M, Zanna I, Corsale S, Amato A, Calo V, Dardanoni G, Morello V, La Farina M, Albanese I, Tomasino RM, Gebbia N, Russo A. Have p53 gene mutations and protein expression a different biological significance in colorectal cancer? J Cell Physiol. 2002 May;191(2):237-46.

Tsai MH, Yang YC, Chen KH, Jiang JK, Chou SJ, Chiang TC, Jan HS, Lou MA. RER and LOH association with sporadic colorectal cancer in Taiwanese patients. Hepatogastroenterology. 2002 May-Jun;49(45):672-7.

Kondo T, Masuda H, Abe Y, Takayama T. Two subtypes in colorectal mucinous carcinoma in relation to microsatellite instability. Hepatogastroenterology. 2002 May-Jun;49(45):660-3.

Canil CM, Tannock IF. Doctor's dilemma: incorporating tumor markers into clinical decision-making. Semin Oncol. 2002 Jun;29(3):286-93.

Mroczko B, Szmitkowski M, Okulczyk B. Granulocyte-colony stimulating factor (G-CSF) and macrophagecolony stimulating factor (M-CSF) in colorectal cancer patients. Clin Chem Lab Med. 2002 Apr;40(4):351-5.

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Kim YH, Lee JH, Chun H, Nam SJ, Lee WY, Song SY, Kwon OJ, Hyun JG, Sung IK, Son HJ, Rhee PL, Kim JJ, Paik SW, Rhee JC, Choi KW. Apoptosis and its correlation with proliferative activity in rectal cancer. J Surg Oncol. 2002 Apr;79(4):236-42.

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Forslund A, Engaras B, Lonnroth C, Lundholm K. Prediction of postoperative survival by preoperative serum concentrations of anti-p53 compared to CEA, CA 50, CA 242 and conventional blood tests in patients with colorectal carcinoma.
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Ichikawa Y, Tsunoda H, Takano K, Oki A, Yoshikawa H. Microsatellite instability and immunohistochemical analysis of MLH1 and MSH2 in normal endometrium, endometrial hyperplasia and endometrial cancer from a hereditary nonpolyposis colorectal cancer patient. Jpn J Clin Oncol. 2002 Mar;32(3):110-2.

Brunagel G, Vietmeier BN, Bauer AJ, Schoen RE, Getzenberg RH.Identification of nuclear matrix protein alterations associated with human colon cancer.
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Chiang JM, Chou YH, Chen TC, Ng KF, Lin JL. Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
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Nakasaki T, Wada H, Shigemori C, Miki C, Gabazza EC, Nobori T, Nakamura S, Shiku H. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer.
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Kruschewski M, Noske A, Haier J, Runkel N, Anagnostopoulos Y, Buhr HJ. Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis?
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Jacob S, Praz F. DNA mismatch repair defects: role in colorectal carcinogenesis. Biochimie. 2002 Jan;84(1):27-47.

Suzuki Y, Honma T, Hayashi S, Ajioka Y, Asakura H.Bcl-2 expression and frequency of apoptosis correlate with morphogenesis of colorectal neoplasia. J Clin Pathol. 2002 Mar;55(3):212-6.

Silva JM, Rodriguez R, Garcia JM, Munoz C, Silva J, Dominguez G, Provencio M, Espana P, Bonilla F. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut. 2002 Apr;50(4):530-4.

Hardy RG, Tselepis C, Hoyland J, Wallis Y, Pretlow TP, Talbot I, Sanders DS, Matthews G, Morton D, Jankowski JA. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut. 2002 Apr;50(4):513-9.

Nishikawa T, Maemura K, Hirata I, Matsuse R, Morikawa H, Toshina K, Murano M, Hashimoto K, Nakagawa Y, Saitoh O, Uchida K, Katsu K. A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis. Clin Chim Acta. 2002 Apr;318(1-2):107-12.

Cascinu S, Graziano F, Catalano V, Staccioli MP, Rossi MC, Baldelli AM, Barni S, Brenna A, Secondino S, Muretto P, Catalano G.An analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of patients treated with adjuvant chemoradiation. Br J Cancer. 2002 Mar 4;86(5):744-9.

Werther K, Christensen IJ, Nielsen HJ.Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma. Br J Cancer. 2002 Feb 1;86(3):417-23.

Corsi DC, Ciaparrone M, Zannoni G, Mancini M, Cassano A, Specchia M, Pozzo C, Martini M, Barone CPredictive value of thymidylate synthase expression in resected metastases of colorectal cancer. Eur J Cancer. 2002 Mar;38(4):527-34.

Kumar A, Collins H, Van Tam J, Scholefield JH, Watson SA. Effect of preoperative radiotherapy on matrilysin gene expression in rectal cancer. Eur J Cancer. 2002 Mar;38(4):505-10.

Rodel C, Grabenbauer GG, Papadopoulos T, Bigalke M, Gunther K, Schick C, Peters A, Sauer R, Rodel F. Apoptosis as a cellular predictor for histopathologic response to neoadjuvant radiochemotherapy in patients with rectal cancer. Int J Radiat Oncol Biol Phys. 2002 Feb 1;52(2):294-303.

Ikenaga M, Tomita N, Sekimoto M, Ohue M, Yamamoto H, Miyake Y, Mishima H, Nishisho I, Kikkawa N, Monden M. Use of microsatellite analysis in young patients with colorectal cancer to identify those with hereditary nonpolyposis colorectal cancer. J Surg Oncol. 2002 Mar;79(3):157-65.

Scartozzi M, Bianchi F, Rosati S, Galizia E, Antolini A, Loretelli C, Piga A, Bearzi I, Cellerino R, Porfiri E. Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer: correlation with microsatellite instability and abnormalities of mismatch repair protein expression. J Clin Oncol. 2002 Mar 1;20(5):1203-8.

Jayne DG, Heath RM, Dewhurst O, Scott N, Guillou PJ. Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer.
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Baker EA, Leaper DJ.Measuring gelatinase activity in colorectal cancer. Eur J Surg Oncol. 2002 Feb;28(1):24-9.

Prix L, Uciechowski P, Bockmann B, Giesing M, Schuetz AJ.Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool. Clin Chem. 2002 Mar;48(3):428-35.

Laiho P, Launonen V, Lahermo P, Esteller M, Guo M, Herman JG, Mecklin JP, Jarvinen H, Sistonen P, Kim KM, Shibata D, Houlston RS, Aaltonen LA.Low-level microsatellite instability in most colorectal carcinomas. Cancer Res. 2002 Feb 15;62(4):1166-70.

Barozzi C, Ravaioli M, D'Errico A, Grazi GL, Poggioli G, Cavrini G, Mazziotti A, Grigioni WF.Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel. Cancer. 2002 Feb 1;94(3):647-57.

Gervaz P, Cerottini JP, Bouzourene H, Hahnloser D, Doan CL, Benhattar J, Chaubert P, Secic M, Gillet M, Carethers JM.Comparison of microsatellite instability and chromosomal instability in predicting survival of patients with T3N0 colorectal cancer. Surgery. 2002 Feb;131(2):190-7.

Suh JH, Lim SD, Kim JC, Hong SH, Kang GH.Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old. Dis Colon Rectum. 2002 Feb;45(2):219-28.

Rosenberg R, Hoos A, Mueller J, Baier P, Stricker D, Werner M, Nekarda H, Siewert JR. Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of node-negative colorectal cancer patients. J Clin Oncol. 2002 Feb 15;20(4):1049-55.

Lindor NM, Burgart LJ, Leontovich O, Goldberg RM, Cunningham JM, Sargent DJ, Walsh-Vockley C, Petersen GM, Walsh MD, Leggett BA, Young JP, Barker MA, Jass JR, Hopper J, Gallinger S, Bapat B, Redston M, Thibodeau SN. Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol. 2002 Feb 15;20(4):1043-8.

Nagy N, Bronckart Y, Camby I, Legendre H, Lahm H, Kaltner H, Hadari Y, Van Ham P, Yeaton P, Pector JC, Zick Y, Salmon I, Danguy A, Kiss R, Gabius HJ. Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor. Gut. 2002 Mar;50(3):392-401.

Wong NA, Pignatelli M.Beta-catenin--a linchpin in colorectal carcinogenesis?
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Marsh S, McKay JA, Curran S, Murray GI, Cassidy J, McLeod HL.Primary colorectal tumour is not an accurate predictor of thymidylate synthase in lymph node metastasis. Oncol Rep. 2002 Mar-Apr;9(2):231-4.

Leahy KM, Ornberg RL, Wang Y, Zweifel BS, Koki AT, Masferrer JL.Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo. Cancer Res. 2002 Feb 1;62(3):625-31.

Trojan J, Raedle J, Herrmann G, Brieger A, Zeuzem S.Detection of microsatellite instability from archival, hematoxylin-eosin-stained colorectal cancer specimen. Arch Pathol Lab Med. 2002 Feb;126(2):202-4.

Oda S, Maehara Y, Sumiyoshi Y, Sugimachi K.Microsatellite instability in cancer: what problems remain unanswered? Surgery. 2002 Jan;131(1 Suppl):S55-62. Review.

Sun XF.p73 overexpression is a prognostic factor in patients with colorectal adenocarcinoma. Clin Cancer Res. 2002 Jan;8(1):165-70.

Munemoto Y, Iida Y, Abe J, Saito H, Fujisawa K, Kasahara Y, Mitsui T, Asada Y, Miura S. Significance of postoperative adjuvant immunochemotherapy after curative resection of colorectal cancers: Association between host or tumor factors and survival. Int J Oncol. 2002 Feb;20(2):403-11.

Yamauchi T, Watanabe M, Kubota T, Hasegawa H, Ishii Y, Endo T, Kabeshima Y, Yorozuya K, Yamamoto K, Mukai M, Kitajima M.Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer.
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Shmuely H, Passaro D, Figer A, Niv Y, Pitlik S, Samra Z, Koren R, Yahav J. Relationship between Helicobacter pylori CagA status and colorectal cancer. Am J Gastroenterol. 2001 Dec;96(12):3406-10.

Pistorius SR, Nagel M, Kruger S, Plaschke J, Kruppa C, Wehrmann U, Schackert HK, Saeger HD. Combined molecular and clinical approach for decision making for surgery in HNPCC patients: a report on three cases in two families. Int J Colorectal Dis. 2001 Nov;16(6):402-7.

 Molnar B, Ladanyi A, Tanko L, Sreter L, Tulassay Z. Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res. 2001 Dec;7(12):4080-5.

Chung GG, Provost E, Kielhorn EP, Charette LA, Smith BL, Rimm DL. Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis. Clin Cancer Res. 2001 Dec;7(12):4013-20.

Hinoi T, Tani M, Lucas PC, Caca K, Dunn RL, Macri E, Loda M, Appelman HD, Cho KR, Fearon ER. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol. 2001 Dec;159(6):2239-48.

Young J, Simms LA, Biden KG, Wynter C, Whitehall V, Karamatic R, George J, Goldblatt J, Walpole I, Robin SA, Borten MM, Stitz R, Searle J, McKeone D, Fraser L, Purdie DR, Podger K, Price R, Buttenshaw R, Walsh MD, Barker M, Leggett BA, Jass JR.  Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol. 2001 Dec;159(6):2107-16.

Gnanasampanthan G, Elsaleh H, McCaul K, Iacopetta B. Ki-ras mutation type and the survival benefit from adjuvant chemotherapy in Dukes' C colorectal cancer. J Pathol. 2001 

Tang R, Ko MC, Wang JY, Changchien CR, Chen HH, Chen JS, Hsu KC, Chiang JM, Hsieh LL. Humoral response to p53 in human colorectal tumors: a prospective study of 1,209 patients. Int J Cancer. 2001 Dec 15;94(6):859-63.

Hemminki K, Li X. Familial colorectal adenocarcinoma from the Swedish Family-Cancer Database. Int J Cancer. 2001 Dec 1;94(5):743-8.

Maaser K, Hopfner M, Jansen A, Weisinger G, Gavish M, Kozikowski AP, Weizman A, Carayon P, Riecken EO, Zeitz M, Scherubl H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br J Cancer. 2001 Nov;85(11):1771-80.

Asakawa H, Koido S, Torii A, Ikegami M. [Alternations of p53 gene, microsatellite instability and proliferation associated antigen Ki-67 in the synchronous multiple colorectal cancers] Nippon Shokakibyo Gakkai Zasshi. 2001 Nov;98(11):1263-71. Japanese.

Weber JC, Schneider A, Rohr S, Nakano H, Bachellier P, Mechine A, Hamel G, Kanor M, Chenard MP, Gaub MP, Oudet P, Meyer C, Jaeck D. Analysis of allelic imbalance in patients with colorectal cancer according to stage and presence of synchronous liver metastases. Ann Surg. 2001 Dec;234(6):795-803.

Cianchi F, Cortesini C, Bechi P, Fantappie O, Messerini L, Vannacci A, Sardi I, Baroni G, Boddi V, Mazzanti R, Masini E. Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. Gastroenterology. 2001 Dec;121(6):1339-47.

El-Bahrawy MA, Poulsom R, Jeffery R, Talbot I, Alison MR. The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol. 2001 Nov;32(11):1216-24.

Harada Y, Ogata Y, Shirouzu K. Expression of vascular endothelial growth factor and its receptor KDR (kinase domain-containing receptor)/Flk-1 (fetal liver kinase-1) as prognostic factors in human colorectal cancer. Int J Clin Oncol. 2001 Oct;6(5):221-8.

Alexiou D, Karayiannakis AJ, Syrigos KN, Zbar A, Kremmyda A, Bramis I, Tsigris C. Serum levels of E-selectin, ICAM-1 and VCAM-1 in colorectal cancer patients: correlations with clinicopathological features, patient survival and tumour surgery. Eur J Cancer. 2001 Dec;37(18):2392-7.

Rooney PH, Boonsong A, McKay JA, Marsh S, Stevenson DA, Murray GI, Curran S, Haites NE, Cassidy J, McLeod HL. Colorectal cancer genomics: evidence for multiple genotypes which influence survival. Br J Cancer. 2001 Nov;85(10):1492-8.

Coleman MG, Gough AC, Bunyan DJ, Braham D, Eccles DM, Primrose JN. Minisatellite instability is found in colorectal tumours with mismatch repair deficiency.
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Hao XP, Pretlow TG, Rao JS, Pretlow TP.Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res. 2001 Nov 15;61(22):8085-8.

Lynch HT, Thorson AG, McComb RD, Franklin BA, Tinley ST, Lynch JF. Familial adenomatous polyposis and extracolonic cancer. Dig Dis Sci. 2001 Nov;46(11):2325-32.

Brown WA, Skinner SA, Vogiagis D, O'Brien PE. Inhibition of beta-catenin translocation in rodent colorectal tumors: a novel explanation for the protective effect of nonsteroidal antiinflammatory drugs in colorectal cancer. Dig Dis Sci. 2001 Nov;46(11):2314-21.

Ponz de Leon M, Varesco L, Benatti P, Sassatelli R, Izzo P, Scarano MI, Rossi GB, Di Gregorio C, Gismondi V, Percesepe A, de Rosa M, Roncucci L. Phenotype-genotype correlations in an extended family with adenomatosis coli and an unusual APC gene mutation. Dis Colon Rectum. 2001 Nov;44(11):1597-604.

Vonlaufen A, Wiedle G, Borisch B, Birrer S, Luder P, Imhof BA. Integrin alpha(v)beta(3) expression in colon carcinoma correlates with survival. Mod Pathol. 2001 Nov;14(11):1126-32.

Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr. 2001 Nov;131(11 Suppl):3109S-20S. Review.

Liu T, Yan H, Kuismanen S, Percesepe A, Bisgaard ML, Pedroni M, Benatti P, Kinzler KW, Vogelstein B, Ponz de Leon M, Peltomaki P, Lindblom A. The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. Cancer Res. 2001 Nov 1;61(21):7798-802.

Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T, Isozaki H, Sharp GB, Shimizu K, Jass J, Tanaka N. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Res. 2001 Nov 1;61(21):7743-6.

Hartwich J, Konturek SJ, Pierzchalski P, Zuchowicz M, Konturek PC, Bielanski W, Marlicz K, Starzynska T, Lawniczak M. Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. Med Sci Monit. 2001 Nov-Dec;7(6):1171-81.

Huerta S, Srivatsan ES, Venkatesan N, Peters J, Moatamed F, Renner S, Livingston EH. Alternative mRNA splicing in colon cancer causes loss of expression of neural cell adhesion molecule.
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Collie-Duguid ES, Johnston SJ, Boyce L, Smith N, Cowieson A, Cassidy J, Murray GI, McLeod HL. Thymidine phosphorylase and dihydropyrimidine dehydrogenase protein expression in colorectal cancer. Int J Cancer. 2001 Oct 15;94(2):297-301.

Grosch S, Tegeder I, Niederberger E, Brautigam L, Geisslinger G.  COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. FASEB J. 2001 Dec;15(14):2742-4.

Heinimann K, Thompson A, Locher A, Furlanetto T, Bader E, Wolf A, Meier R, Walter K, Bauerfeind P, Marra G, Muller H, Foernzler D, Dobbie Z. Nontruncating APC germ-line mutations and mismatch repair deficiency play a minor role  APC mutation-negative polyposis. Cancer Res. 2001 Oct 15;61(20):7616-22.

Feng J, Hua F, Shuo R, Chongfeng G, Huimian X, Nakajima T, Subao W, Tsuchida N. Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. Oncol Rep. 2001 Nov-Dec;8(6):1409-13.

Ramsey SD, Clarke L, Etzioni R, Higashi M, Berry K, Urban N. Cost-effectiveness of microsatellite instability screening as a method for detecting hereditary nonpolyposis colorectal cancer.

Raedle J, Trojan J, Brieger A, Weber N, Schafer D, Plotz G, Staib-Sebler E, Kriener S, Lorenz M, Zeuzem S. Bethesda guidelines: relation to microsatellite instability and MLH1 promoter methylation in patients with colorectal cancer. Ann Intern Med. 2001 Oct 16;135(8 Pt 1):566-76.

Vasen HF, Stormorken A, Menko FH, Nagengast FM, Kleibeuker JH, Griffioen G, Taal BG, Moller P, Wijnen JT. MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. J Clin Oncol. 2001 Oct 15;19(20):4074-80.

Slattery ML, Anderson K, Curtin K, Ma K, Schaffer D, Edwards S, Samowitz W. Lifestyle factors and Ki-ras mutations in colon cancer tumors. Mutat Res. 2001 Nov 1;483(1-2):73-81.

Buckhaults P, Rago C, St Croix B, Romans KE, Saha S, Zhang L, Vogelstein B, Kinzler KW. Secreted and cell surface genes expressed in benign and malignant colorectal tumors. Cancer Res. 2001 Oct 1;61(19):6996-7001.

Crabtree MD, Tomlinson IP, Talbot IC, Phillips RK. Variability in the severity of colonic disease in familial adenomatous polyposis results from differences in tumour initiation rather than progression and depends relatively little on patient age. Gut. 2001 Oct;49(4):540-3.

Xiao ZQ, Moragoda L, Jaszewski R, Hatfield JA, Fligiel SE, Majumdar AP.  Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. Mech Ageing Dev. 2001 Oct;122(15):1849-64.

Cunningham JM, Kim CY, Christensen ER, Tester DJ, Parc Y, Burgart LJ, Halling KC, McDonnell SK, Schaid DJ, Walsh Vockley C, Kubly V, Nelson H, Michels VV, Thibodeau SN. The frequency of hereditary defective mismatch repair in a prospective series of unselected colorectal carcinomas. Am J Hum Genet. 2001 Oct;69(4):780-90.

Zeng Z, Sun Y, Shu W, Guillem JG. Tissue inhibitor of metalloproteinase-3 is a basement membrane-associated protein that is significantly decreased in human colorectal cancer. Dis Colon Rectum. 2001 Sep;44(9):1290-6.

Wullenweber HP, Sutter C, Autschbach F, Willeke F, Kienle P, Benner A, Bahring J, Kadmon M, Herfarth C, von Knebel Doeberitz M, Gebert J. Evaluation of Bethesda guidelines in relation to microsatellite instability. Dis Colon Rectum. 2001 Sep;44(9):1281-9.

Mesri M, Wall NR, Li J, Kim RW, Altieri DC. Cancer gene therapy using a survivin mutant adenovirus. J Clin Invest. 2001 Oct;108(7):981-90.

Percesepe A, Borghi F, Menigatti M, Losi L, Foroni M, Di Gregorio C, Rossi G, Pedroni M, Sala E, Vaccina F, Roncucci L, Benatti P, Viel A, Genuardi M, Marra G, Kristo P, Peltomaki P, Ponz de Leon M. Molecular screening for hereditary nonpolyposis colorectal cancer: a prospective, population-based study. J Clin Oncol. 2001 Oct 1;19(19):3944-50.

Nakamura H. [Cyclooxygenase (COX)-2 selective inhibitors: aspirin, a dual COX-1/COX-2 inhibitor, to COX-2 selective inhibitors]. Nippon Yakurigaku Zasshi. 2001 Sep;118(3):219-30. Japanese.

Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer. 2001 Sep 1;92(5):1331-46.

Sadahiro S, Suzuki T, Tokunaga N, Yurimoto S, Yasuda S, Tajima T, Makuuchi H, Murayama C, Matsuda K. Detection of tumor cells in the portal and peripheral blood of patients with colorectal carcinoma using competitive reverse transcriptase-polymerase chain reaction. Cancer. 2001 Sep 1;92(5):1251-8.

Ahmad SA, Liu W, Jung YD, Fan F, Reinmuth N, Bucana CD, Ellis LM. Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of angiogenesis. Cancer. 2001 Sep 1;92(5):1138-43.

Debniak T, Gorski B, Cybulski C, Jakubowska A, Kurzawski G, Kladny J, Lubinski J. Comparison of Alu-PCR, microsatelite instability, and immunohistochemical analyses in finding features characteristic for hereditary nonpolyposis colorectal cancer. J Cancer Res Clin Oncol. 2001 Sep;127(9):565-9.

Jubb AM, Bell SM, Quirke P. Methylation and colorectal cancer. J Pathol. 2001 Sep;195(1):111-34. Review.

Xiao Z, Moragoda L, Jaszewski R, Hatfield JA, Fligiel SE, Majumdar AP. Aging is associated with increased proliferation and decreased apoptosis in the colonic mucosa. Mech Ageing Dev. 2001 Oct;122(15):1849-64.

Buglioni S, D'Agnano I, Vasselli S, Perrone Donnorso R, D'Angelo C, Brenna A, Benevolo M, Cosimelli M, Zupi G, Mottolese M. p53 nuclear accumulation and multiploidy are adverse prognostic factors in surgically resected stage II colorectal cancers independent of fluorouracil-based adjuvant therapy. Am J Clin Pathol. 2001 Sep;116(3):360-8.

Benamouzig R, Yoon H, Little J, Martin A, Couturier D, Deyra J, Coste T, Chaussade S. APACC, a French prospective study on aspirin efficacy in reducing colorectal adenoma recurrence: design and baseline findings. Eur J Cancer Prev. 2001 Aug;10(4):327-35.

Oh-e H, Tanaka S, Kitadai Y, Shimamoto F, Yoshihara M, Haruma K. Angiogenesis at the site of deepest penetration predicts lymph node metastasis of submucosal colorectal cancer. Dis Colon Rectum. 2001 Aug;44(8):1129-36.

Pocard M, Debruyne P, Bras-Goncalves R, Mareel M, Dutrillaux B, Poupon MF. Single alteration of p53 or E-cadherin genes can alter the surgical resection benefit in an experimental model of colon cancer. Dis Colon Rectum. 2001 Aug;44(8):1106-12.

Ma J, Giovannucci E, Pollak M, Chan JM, Gaziano JM, Willett W, Stampfer MJ. Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. J Natl Cancer Inst. 2001 Sep 5;93(17):1330-6.

Akedo I, Ishikawa H, Ioka T, Kaji I, Narahara H, Ishiguro S, Suzuki T, Otani T. Evaluation of epithelial cell proliferation rate in normal-appearing colonic mucosa as a high-risk marker for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):925-30.

Mashino K, Sadanaga N, Tanaka F, Yamaguchi H, Nagashima H, Inoue H, Sugimachi K, Mori M. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br J Cancer. 2001 Sep 1;85(5):713-20.

Andreyev HJ, Norman AR, Cunningham D, Oates J, Dix BR, Iacopetta BJ, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes HM, Zietz C, Troungos C, Valavanis C, Yuen ST, Ho JW, Croke CT, O'Donoghue DP, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, de Goeij AF, Arends JW, Andersen SN, Lovig T, Breivik J, Gaudernack G, Clausen OP, De Angelis PD, Meling GI, Rognum TO, Smith R, Goh HS, Font A, Rosell R, Sun XF, Zhang H, Benhattar J, Losi L, Lee JQ, Wang ST, Clarke PA, Bell S, Quirke P, Bubb VJ, Piris J, Cruickshank NR, Morton D, Fox JC, Al-Mulla F, Lees N, Hall CN, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo VE, Finkelstein SD, Thebo JS, Senagore AJ, Halter SA, Wadler S, Malik S, Krtolica K, Urosevic N. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer. 2001 Sep 1;85(5):692-6.

Gebauer G, Muller-Ruchholtz W. Carcinoembryonic antigen and CA19-9: implications of quantitative marker measurement in tissues for prognosis of colorectal cancer. Cancer Detect Prev. 2001;25(4):344-51.

Ryan BM, Weir DG. Relevance of folate metabolism in the pathogenesis of colorectal cancer.
J Lab Clin Med. 2001 Sep;138(3):164-76. Review.

Ikeda Y, Oda S, Abe T, Ohno S, Maehara Y, Sugimachi K. Features of Microsatellite Instability in Colorectal Cancer: Comparison between Colon and Rectum. Oncology. 2001 Aug;61(2):168-74.

Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, Hamelin R. Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. Oncogene. 2001 Aug 16;20(36):5025-32.

Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, Knuechel R, Kirchner T. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10356-61.

Elkablawy MA, Maxwell P, Williamson K, Anderson N, Hamilton PW. Apoptosis and cell-cycle regulatory proteins in colorectal carcinoma: relationship to tumour stage and patient survival.
J Pathol. 2001 Aug;194(4):436-43.

Takayama T, Ohi M, Hayashi T, Miyanishi K, Nobuoka A, Nakajima T, Satoh T, Takimoto R, Kato J, Sakamaki S, Niitsu Y. Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis. Gastroenterology. 2001 Sep;121(3):599-611.

Nanashima A, Yamaguchi H, Sawai T, Yamaguchi E, Kidogawa H, Matsuo S, Yasutake T, Tsuji T, Jibiki M, Nakagoe T, Ayabe H. Prognostic factors in hepatic metastases of colorectal carcinoma: immunohistochemical analysis of tumor biological factors. Dig Dis Sci. 2001 Aug;46(8):1623-8.

Togo G, Shiratori Y, Okamoto M, Yamaji Y, Matsumura M, Sano T, Motojima T, Omata M. Relationship between grade of microsatellite instability and target genes of mismatch repair pathways in sporadic colorectal carcinoma. Dig Dis Sci. 2001 Aug;46(8):1615-22.

Shaheen RM, Ahmad SA, Liu W, Reinmuth N, Jung YD, Tseng WW, Drazan KE, Bucana CD, Hicklin DJ, Ellis LM. Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer. 2001 Aug 17;85(4):584-9.

Nasierowska-Guttmejer A.The comparison of immunohistochemical proliferation and apoptosis markers in rectal carcinoma treated surgically or by preoperative radio-chemotherapy. Pol J Pathol. 2001;52(1-2):53-61.

Abe T, Sakaguchi Y, Ohno S, Ikeda Y, Kitamura K, Maehara Y, Sugimachi K. Apoptosis and p53 overexpression in human rectal cancer; relationship with response to hyperthermo-chemo-radiotherapy. Anticancer Res. 2001 May-Jun;21(3C):2115-20.

Brett D, Kemmner W, Koch G, Roefzaad C, Gross S, Schlag PM. A rapid bioinformatic method identifies novel genes with direct clinical relevance to colon cancer. Oncogene. 2001 Jul 27;20(33):4581-5.

Zhang Z, DuBois RN. Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. Oncogene. 2001 Jul 27;20(33):4450-6.

Forslund A, Kressner U, Lindmark G, Inganas M, Lundholm K. Serum anti-p53 in relation to mutations across the entire translated p53 gene in colorectal carcinomas. Int J Oncol. 2001 Sep;19(3):501-6.

Michael-Robinson JM, Reid LE, Purdie DM, Biemer-Huttmann AE, Walsh MD, Pandeya N, Simms LA, Young JP, Leggett BA, Jass JR, Radford-Smith GL. Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. Clin Cancer Res. 2001 Aug;7(8):2347-56.

Maltzman T, Knoll K, Martinez ME, Byers T, Stevens BR, Marshall JR, Reid ME, Einspahr J, Hart N, Bhattacharyya AK, Kramer CB, Sampliner R, Alberts DS, Ahnen DJ. Ki-ras proto-oncogene mutations in sporadic colorectal adenomas: relationship to histologic and clinical characteristics. Gastroenterology. 2001 Aug;121(2):302-9.

Duchrow M, Hasemeyer S, Broll R, Bruch HP, Windhovel U. Assessment of proliferative activity in colorectal carcinomas by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Cancer Invest. 2001;19(6):588-96.

Backus HH, van Riel JM, van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Peters GJ. Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. Ann Oncol. 2001 Jun;12(6):779-85.

Takemasa I, Higuchi H, Yamamoto H, Sekimoto M, Tomita N, Nakamori S, Matoba R, Monden M, Matsubara K. Construction of preferential cDNA microarray specialized for human colorectal carcinoma: molecular sketch of colorectal cancer. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1244-9.

Slattery ML, Anderson K, Curtin K, Ma KN, Schaffer D, Samowitz W. Dietary intake and microsatellite instability in colon tumors. Int J Cancer. 2001 Aug 15;93(4):601-7.

Houlston RS. What we could do now: molecular pathology of colorectal cancer. Mol Pathol. 2001 Aug;54(4):206-14. Review.

Karelia NH, Patel DD, Desai NS, Mehta HV, Yadav PK, Patel SM, Kothari KC, Shah PM. Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities. Int J Biol Markers. 2001 Apr-Jun;16(2):97-104.

Golijow C, Guerci A, Mouron S, Abba M, Dulout FN, Ottino A, Pianzola H. [Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]. Acta Gastroenterol Latinoam. 2001 May;31(2):71-6. Spanish.

Chan CC, Menges M, Orzechowski HD, Orendain N, Pistorius G, Feifel G, Zeitz M, Stallmach A. Increased matrix metalloproteinase 2 concentration and transcript expression in advanced colorectal carcinomas. Int J Colorectal Dis. 2001 Jun;16(3):133-40.

Ikeguchi M, Makino M, Kaibara N. Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma. J Surg Oncol. 2001 Jul;77(3):201-7.

Lagares-Garcia JA, Moore RA, Collier B, Heggere M, Diaz F, Qian F. Nitric oxide synthase as a marker in colorectal carcinoma. Am Surg. 2001 Jul;67(7):709-13.

Clin Cancer Res 2000 Sep;6(9):3545-51 Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration. Etoh T, Shibuta K, Barnard GF, Kitano S, Mori M

Clin Cancer Res 2000 Sep;6(9):3499-504 P53 mutations in primary and metastatic tumors and circulating tumor cells from colorectal carcinoma patients. Khan ZA, Jonas SK, Le-Marer N, Patel H, Wharton RQ, Tarragona A, Ivison A, Allen-Mersh TG

Br J Surg 2000 Sep;87(9):1197-1202 Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Wright CM, Dent OF, Barker M, Newland RC, Chapuis PH, Bokey EL, Young JP, Leggett BA, Jass JR, MacDonald GA

Cancer 2000 Sep 1;89(5):970-6 Prognostic significance of reverse transcriptase-polymerase chain reaction measurement of carcinoembryonic antigen mRNA levels in tumor drainage blood and peripheral blood of patients with colorectal carcinoma. Taniguchi T, Makino M, Suzuki K, Kaibara N

Int J Cancer 2000 Oct 1;88(1):77-81 Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative. McKay JA, Douglas JJ, Ross VG, Curran S, Murray GI, Cassidy J, McLeod HL

Dis Colon Rectum 2000 Aug;43(8):1133-40 Relationship between colorectal cancer glutathione levels and patient survival: early results. Barranco SC, Perry RR, Durm ME, Quraishi M, Werner AL, Gregorcyk SG, Kolm P

Anticancer Res 2000 May-Jun;20(3A):1695-701 The prognostic value of the presence of mutations at the codons 12, 13, 61 of K-ras oncogene in colorectal cancer. Pajkos G, Kiss I, Sandor J, Ember I, Kishazi P

Dis Colon Rectum 2000 Jul;43(7):971-5 Prognostic influence of p53 nuclear overexpression in colorectal carcinoma. Gallego MG, Acenero MJ, Ortega S, Delgado AA, Cantero JL

Ceylon Med J 1999 Dec;44(4):162-5 Developing a molecular marker for metachronous colorectal cancer. de Silva WM

Arch Pathol Lab Med 2000 Jul;124(7):979-94 Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Compton CC, Fielding LP, Burgart LJ, Conley B, Cooper HS, Hamilton SR, Hammond ME, Henson DE, Hutter RV, Nagle RB, Nielsen ML, Sargent DJ, Taylor CR, Welton M, Willett C

Eur J Cancer 2000 May;36(8):1008-15 p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer. Bouzourene H, Gervaz P, Cerottini JP, Benhattar J, Chaubert P, Saraga E, Pampallona S, Bosman FT, Givel JC

Cancer 2000 Jun 15;88(12):2661-7 Allelic loss is heterogeneous throughout the tumor in colorectal carcinoma. Lindforss U, Fredholm H, Papadogiannakis N, Gad A, Zetterquist H, Olivecrona H

J Surg Res 2000 Jul;92(1):78-84 p27(kip1) expression in rectal cancer correlates with disease-free survival. Gunther K, Jung A, Volker U, Meyer M, Brabletz T, Matzel KE, Reymond MA, Kirchner T, Hohenberger W

Int J Cancer 2000 May 20;89(3):213-6 Down-regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas. Yao J, Eu KW, Seow-Choen F, Cheah PY

Am J Clin Oncol 2000 Jun;23(3):263-6 Preoperative elevation of serum C-reactive protein is related to impaired immunity in patients with colorectal cancer. Nozoe T, Matsumata T, Sugimachi K

Croat Med J 2000 Jun;41(2):154-8 Prognostic significance of DNA ploidy pattern and nucleolar organizer regions (AgNOR) in colorectal carcinoma. Eminovic-Behrem S, Trobonjaca Z, Petrovecki M, Dobi-Babic R, Dujmovic M, Jonjic N

Cancer Res 2000 Jun 1;60(11):3043-50 Overexpression of CDC25B phosphatase as a novel marker of poor prognosis of human colorectal carcinoma. Takemasa I, Yamamoto H, Sekimoto M, Ohue M, Noura S, Miyake Y, Matsumoto T, Aihara T, Tomita N, Tamaki Y, Sakita I, Kikkawa N, Matsuura N, Shiozaki H, Monden M

Cancer Res 2000 Jun 1;60(11):2892-7 Color Doppler vascularity index can predict distant metastasis and survival in colon cancer patients. Chen CN, Cheng YM, Liang JT, Lee PH, Hsieh FJ, Yuan RH, Wang SM, Chang MF, Chang KJ

Eur J Gastroenterol Hepatol 2000 May;12(5):549-52 The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome. Clarke G, Ryan E, O'Keane JC, Crowe J, MacMathuna P

Minerva Chir 2000 Mar;55(3):99-104 Characterization and prognostic value of colorectal adenomas with molecular genetic markers [Article in Italian] Di Stefano A, Fisichella P, Catanuto G, Di Blasi M, La Greca G, Grasso G, Russello D

Oncologist 2000;5(2):108-14 MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer. Sunami E, Tsuno N, Osada T, Saito S, Kitayama J, Tomozawa S, Tsuruo T, Shibata Y, Muto T, Nagawa H

Dis Colon Rectum 2000 Apr;43(4):451-9 Molecular prognostic factors in rectal cancer treated by radiation and surgery. Qiu H, Sirivongs P, Rothenberger M, Rothenberger DA, Garcia-Aguilar Jx

J Cancer Res Clin Oncol 2000 Apr;126(4):205-11 Expression of erbB-3 protein in colorectal adenocarcinoma: correlation with poor survival. Kapitanovic S, Radosevic S, Slade N, Kapitanovic M, Andelinovic S, Ferencic Z,Tavassoli M, Spaventi S, Pavelic K, Spaventi R

Eur J Cancer Prev 1999 Dec;8 Suppl 1:S21-5 Nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer. Stockbrugger RW

Gut 2000 May;46(5):645-50 Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma. Sarela AI, Macadam RC, Farmery SM, Markham AF, Guillou PJ

Am J Gastroenterol 2000 Apr;95(4):1056-61 Prognostic significance of circulating antibodies against carcinoembryonic antigen (anti-CEA) in patients with colon cancer. Albanopoulos K, Armakolas A, Konstadoulakis MM, Leandros E, Tsiobanou E,Katsaragakis S, Alexiou D, Androulakis G

Eur J Cancer 2000 Apr;36(6):748-53 Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Lee JC, Chow NH, Wang ST, Huang SM

J Cell Biochem Suppl 2000;34:23-7 Implications of low COX-2 expression in colorectal neoplasms with defective DNA mismatch repair. Karnes WE Jr

Cancer 2000 Apr 15;88(8):1814-9 p53 tumor suppressor gene mutations predict decreased survival of patients with sporadic colorectal carcinoma. Kahlenberg MS, Stoler DL, Rodriguez-Bigas MA, Weber TK, Driscoll DL, Anderson GR, Petrelli NJ

Eur J Gastroenterol Hepatol 1999 May;11(5):547-52 p53 protein accumulation and colonic adenoma recurrence. Triantafyllou K, Paspatis GA, Zizi A, Papatheodoridis GV, Tzouvala M,Chlouverakis GJ, Elemenoglou I, Karamanolis DG

Eur J Cancer 2000 Jan;36(1):55-60 Vascular enumeration as a prognosticator for colorectal carcinoma. Galindo Gallego M, Fernandez Acenero MJ, Sanz Ortega J, Aljama A

Cancer 2000 Apr 1;88(7):1739-57 American Joint Committee on Cancer Prognostic Factors Consensus Conference:Colorectal Working Group. Compton C, Fenoglio-Preiser CM, Pettigrew N, Fielding LP

Cancer 2000 Apr 1;88(7):1536-43 Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: A clinicopathologic study of 264 patients. Baldus SE, Zirbes TK, Hanisch FG, Kunze D, Shafizadeh ST, Nolden S, Monig SP, Schneider PM, Karsten U, Thiele J, Holscher AH, Dienes HP

Int J Cancer 2000 Jan 20;89(1):14-8 Prognostic impact of p21/waf1/cip1 in colorectal cancer. Zirbes TK, Baldus SE, Moenig SP, Nolden S, Kunze D, Shafizadeh ST, Schneider PM, Thiele J, Hoelscher AH, Dienes HP

Int J Cancer 2000 Jan 20;89(1):1-7 Genomic alterations (LOH, MI) on chromosome 17q21-23 and prognosis of sporadic colorectal cancer. Berney CR, Fisher RJ, Yang J, Russell PJ, Crowe PJ

Int J Mol Med 2000 Apr;5(4):373-8 Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma. Maeda K, Nishiguchi Y, Yashiro M, Yamada S, Onoda N, Sawada T, Kang SM, Hirakawa K

Diagn Mol Pathol 2000 Mar;9(1):35-40 A proposal for the integration of immunohistochemical staining and DNA-based techniques for the determination of TP53 mutations in human carcinomas. Logullo AF, de Moura RP, Nonogaki S, Kowalski LP, Nagai MA, Simpson AJ

Cancer 2000 Mar 15;88(6):1304-9 Quantification of telomerase activity in sporadic colorectal carcinoma: association with tumor growth and venous invasion. Shoji Y, Yoshinaga K, Inoue A, Iwasaki A, Sugihara K

Eur J Cancer 2000 Feb;36(3):348-56 p53 and Bcl-2 as significant predictors of recurrence and survival in rectal cancer. Schwandner O, Schiedeck TH, Bruch HP, Duchrow M, Windhoevel U, Broll R

Dig Dis Sci 2000 Jan;45(1):122-8 Circulating p53 antibody in patients with colorectal cancer: relation to clinicopathologic features and survival. Shiota G, Ishida M, Noguchi N, Oyama K, Takano Y, Okubo M, Katayama S, Tomie Y, Harada K, Hori K, Ashida K, Kishimoto Y, Hosoda A, Suou T, Kanbe T, Tanaka K, Nosaka K, Tanida O, Kojo H, Miura K, Ito H, Kaibara N, Kawasaki H

Trop Gastroenterol 1999 Jul-Sep;20(3):107-10 Clinical significance of carcinoembryonic antigen in colorectal malignancy. Mazumdar A, Verma GR, Bose SM, Ganguly NK

Clin Cancer Res 2000 Feb;6(2):488-92 Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival. Edler D, Kressner U, Ragnhammar P, Johnston PG, Magnusson I, Glimelius B, Pahlman L, Lindmark G, Blomgren H

Hua Hsi I Ko Ta Hsueh Hsueh Pao 1998 Jun;29(2):182-4 Prognostic significance of P53 protein expression in patients with colorectal adenocarcinoma. [Article in Chinese] Wang Q, Zhao P, Hu Y, Yang G

Br J Cancer 2000 Feb;82(3):560-7 Thymidilate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Paradiso A, Simone G, Petroni S, Leone B, Vallejo C, Lacava J, Romero A, Machiavelli M, De Lena M, Allegra CJ, Johnston PG

Eur J Histochem 1999;43(4):311-6 Immunohistochemical detection of mutant p53 protein in regional lymph nodes is associated with adverse outcome in stage II colorectal cancer. Clarke G, Ryan E, Crowe J, O'Keane JC, MacMathuna P

Histopathology 2000 Feb;36(2):121-6 Histopathological grade, mucinous differentiation and DNA ploidy in relation to  rognosis in colorectal carcinoma. Purdie CA, Piris J

Oncol Rep 2000 Mar-Apr;7(2):333-8 Clinical significance of serum vascular endothelial growth factor in colorectal cancer patients: correlation with clinicopathological factors and tumor markers. Takeda A, Shimada H, Imaseki H, Okazumi S, Natsume T, Suzuki T, Ochiai T

Int J Colorectal Dis 1999 Dec;14(6):272-6 The prognostic significance of tumor vascularization in patients with localized colorectal cancer. Sternfeld T, Foss HD, Kruschewski M, Runkel N

Int J Colorectal Dis 1999 Nov;14(4-5):194-200 Towards a molecular classification of colorectal cancer. Jass JR

Oncology 2000;58(1):52-9 p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma. Elsaleh H, Powell B, Soontrapornchai P, Joseph D, Goria F, Spry N, Iacopetta B

Oncology 2000;58(1):45-51 Prognostic significance of p27(kip1) protein expression and spontaneousapoptosis in patients with colorectal adenocarcinomas.Tenjo T, Toyoda M, Okuda J, Watanabe I, Yamamoto T, Tanaka K, Ohtani M, Nohara T, Kawasaki H, Tanigawa N

Ann Surg 2000 Jan;231(1):11-24 Cell surface molecules and their prognostic values in assessing colorectal carcinomas.Haier J, Nasralla M, Nicolson GL

J Clin Lab Anal 1999;13(6):291-5 p27 cell-cycle inhibitor is inversely correlated with lymph node metastases in right-sided colon cancer. Liu DF, Ferguson K, Cooper GS, Grady WM, Willis J

Clin Cancer Res 1999 Dec;5(12):4126-32 Evaluation of four antibodies in detecting p53 protein for predicting clinicopathological and prognostic significance in colorectal adenocarcinoma. Zhang Hong

N Engl J Med 2000 Jan 13;342(2):69-77 Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. Gryfe R, Kim H, Hsieh ET, Aronson MD, Holowaty EJ, Bull SB, Redston M, Gallinger S

Hepatogastroenterology 1999 Nov-Dec;46(30):3109-14 P53 overexpression in colorectal metastases confined to the liver and outcome of liver resection. Heisterkamp J, van Bommel J, Hop WC, Tilanus HW, Zondervan PE, IJzermans JN

Anal Quant Cytol Histol 1999 Dec;21(6):468-72 DNA quantification as a prognostic factor in colorectal adenocarcinoma. Azua J, Romeo P, Morales M, Castiella T, Azua J Jr

Cancer 2000 Jan 1;88(1):42-9 Expression of platelet-derived endothelial cell growth factor correlates with good prognosis in patients with colorectal carcinoma. Saito S, Tsuno N, Nagawa H, Sunami E, Zhengxi J, Osada T, Kitayama J, Shibata Y, Tsuruo T, Muto T

Int J Oncol 2000 Jan;16(1):169-79 Molecular profiling of sporadic colorectal tumors by microsatellite analysis. Gebert J, Sun M, Ridder R, Hinz U, Lehnert T, Moller P, Schackert HK, Herfarth C, von Knebel Doeberitz M

Int J Oncol 2000 Jan;16(1):55-64 Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer. Kimura T, Tanaka S, Haruma K, Sumii K, Kajiyama G, Shimamoto F, Kohno N

Cancer 1999 Dec 1;86(11):2436-46 American Joint Committee on Cancer prognostic factors consensus conference. Yarbro JW, Page DL, Fielding LP, Partridge EE, Murphy GP

J Surg Oncol 1999 Dec;72(4):225-9 Expression of receptors for estrogen and progesterone in malignant colonic mucosa as a prognostic factor for patient survival. Kaklamanos IG, Bathe OF, Franceschi D, Lazaris AC, Davaris P, Glinatsis M, Golematis BC

Surg Today 1999;29(10):983-91 Tumor angiogenesis predicts recurrence with normal serum carcinoembryonic antigen in advanced rectal carcinoma patients. Ishikawa H, Fujii H, Yamamoto K, Morita T, Hata M, Koyama F, Terauchi S, Sugimori S, Kobayashi T, Enomoto H, Yoshikawa S, Nishikawa T, Nakano H

Bratisl Lek Listy 1999 Jun;100(6):308-11 Preoperative levels of CEA and survival in patients with surgical treatment of colorectal carcinoma. [Article in Slovak] Pechan J, Pribelsky M, Okolicany R

Int J Oncol 1999 Dec;15(6):